Busca avançada
Ano de início
Entree
(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Behavioural profile of Wistar rats with unilateral striatal lesion by quinolinic acid (animal model of Huntington disease) post-injection of apomorphine and exposure to static magnetic field

Texto completo
Autor(es):
Giorgetto, Carolina [1] ; Mazzei Silva, Elaine Cristina [1] ; Kitabatake, Takae Tamy [1] ; Bertolino, Guilherme [1] ; de Araujo, Joao Eduardo [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Lab Neuropsychobiol & Motor Behav, Dept Biomech Med & Rehabil Locomotor Syst, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Experimental Brain Research; v. 233, n. 5, p. 1455-1462, MAY 2015.
Citações Web of Science: 2
Resumo

We analysed the motor behaviour of Wistar rats after 7 days lesion in the left striatum, injected with apomorphine (APO) and stimulated by a continuous magnetic field of 3,200 Gauss. For the behaviour assessment, we utilised the activity cage test and the rotarod test. Sixty-eight male Wistar rats were divided into six groups: control, sham, sham magnetic, lesion, and stimulated South and North Poles. After the experiments, coronal sections of the striatum were taken and stained with Nissl for analysis of the lesion. In the activity cage test for distance (F = 3.19), time of activity (F = 5.46) and crossings (F = 3.31) in all groups, except for the North Pole-stimulated group, we observed a significant increase in these behaviours when compared to the control group. Considering the number of counterclockwise turns, we observed a significant increase in the lesion in the South and North Pole stimulation groups compared with the control group. Highlighting the minor number of counterclockwise turns observed in the North Pole-stimulated group in relation to the South Pole-stimulated and Lesion groups (F = 16.01). The rotarod test revealed a decrease in the time spent in this apparatus for the Lesion group when compared to all other groups (F = 5.46). The morphometric analysis showed a reduction in the number of neurons in the Lesion group in relation to all other groups (F = 5.13). Thus, the results suggest that the static magnetic field north and south promoted a distinct behavioural profile and morphological preservation after 7 days of lesion with quinolinic acid associated with APO. (AU)

Processo FAPESP: 07/04560-0 - Efeitos comportamentais e alterações apoptóticas neuroniais eliciadas pelo campo magnético contínuo em diferentes regiões do sistema nervoso central após lesões experimentalmente induzidas
Beneficiário:João Eduardo de Araujo
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores