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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Heart Rate Detrended Fluctuation Indexes as Estimate of Obstructive Sleep Apnea Severity

Texto completo
Autor(es):
Pereira da Silva, Eduardo Luiz [1, 2] ; Pereira, Rafael [3] ; Reis, Luciano Neves [4] ; Pereira, Jr., Valter Luis [1] ; Campos, Luciana Aparecida [1] ; Wessel, Niels [5] ; Baltatu, Ovidiu Constantin [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Camilo Castelo Branco Univ UNICASTELO, CITE, BR-12247016 Sao Jose Dos Campos, SP - Brazil
[2] Univ Iguacu Campus V, Rio De Janeiro - Brazil
[3] State Univ Southwest Bahia UESB, Dept Biol Sci, Jequie, BA - Brazil
[4] Sleep Inst Itaperuna, Rio De Janeiro - Brazil
[5] Humboldt Univ, D-10099 Berlin - Germany
Número total de Afiliações: 5
Tipo de documento: Artigo Científico
Fonte: MEDICINE; v. 94, n. 4 JAN 2015.
Citações Web of Science: 5
Resumo

In the present study, we aimed at investigating a heart rate variability (HRV) biomarker that could be associated with the severity of the apnea-hypopnea index (AHI), which could be used for an early diagnosis of obstructive sleep apnea (OSA). This was a cross-sectional observational study on 47 patients (age 36 + 9.2 standard deviation) diagnosed with mild (23.4%), moderate (34%), or severe (42.6%) OSA. HRV was studied by linear measures of fast Fourier transform, nonlinear Poincare analysis, and detrended fluctuation analysis (DFA)-DFA alpha 1 characterizes short-term fluctuations, DFA alpha 2 characterizes long-term fluctuations. Associations between polysomnography indexes (AHI, arousal index {[}AI], and oxygen desaturation index {[}ODI]) and HRV indexes were studied. Patients with different grades of AHI had similar sympathovagal balance levels as indicated by the frequency-domain and Poincare HRV indexes. The DFA alpha 2 index was significantly positive correlated with AHI, AI, and ODI (Pearson r: 0.55, 0.59, and 0.59, respectively, with P < 0.0001). The ROC analysis revealed that DFA alpha 2 index predicted moderate and severe OSA with a sensitivity/specificity/area under the curve of 0.86/0.64/0.8 (P = 0.005) and 0.6/0.89/0.76 (P = 0.003), respectively. Our data indicate that the DFA alpha 2 index may be used as a reliable index for the detection of OSA severity. (AU)

Processo FAPESP: 13/06698-0 - Biomarcadores matemáticos para regulação autonômica do sistema cardiovascular
Beneficiário:Luciana Aparecida Campos Baltatu
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/14724-0 - Biomarcadores funcionais na doença vascular extracraniana
Beneficiário:Ovidiu Constantin Baltatu
Linha de fomento: Auxílio à Pesquisa - Regular