| Texto completo | |
| Autor(es): |
Vieira, Luiz Angelo
[1]
;
De Marchi, Patricia Leme
[2]
;
dos Santos, Aline Amaro
[1]
;
Christofolini, Denise Maria
[2]
;
Barbosa, Caio Parente
[2]
;
Affonso Fonseca, Fernando Luiz
[3]
;
Bianco, Bianca
[2]
;
Rodrigues, Luciano Miller R.
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Fac Med ABC, Dept Surg, Div Orthoped & Traumatol, BR-09060650 Santo Andre, SP - Brazil
[2] Fac Med ABC, Ctr Human Reprod & Genet, Dept Gynecol & Obstet, Genet Lab, BR-09060650 Santo Andre, SP - Brazil
[3] Fac Med ABC, Dept Clin Med, Lab Clin Anal, BR-09060650 Santo Andre, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | GENETIC TESTING AND MOLECULAR BIOMARKERS; v. 18, n. 9, p. 625-629, SEP 2014. |
| Citações Web of Science: | 20 |
| Resumo | |
Aim: We have hypothesized a possible relationship between disc degeneration (DD) and VDR FokI/T2C polymorphism. Methods: A case-control study was performed comprising 121 Brazilian patients with confirmed DD by nuclear magnetic resonance and a control group consisting of 131 healthy patients without a history of disc cysts of the lumbar spine. Detection of VDR FokI/T2C polymorphism was performed using restriction fragment length polymorphism-polymerase chain reaction. The chi-square test was used to compare allele and genotype frequencies between groups, and a p-value of < 0.05 was considered statistically significant. Results: The results disclosed statistical difference between allele distribution among cases and controls (p = 0.025, odds ratio = 1.58, confidence interval = 1.07-2.32) considering VDR FokI/T2C polymorphism. Conclusion: The results showed a positive association between VDR FokI/T2C polymorphism and DD in Brazilian patients tested. (AU) | |
| Processo FAPESP: | 13/00902-4 - Avaliação da frequência de polimorfismos do gene do receptor da Vitamina D (VDR) como fator de risco na etiologia da degeneração discal |
| Beneficiário: | Luciano Miller Reis Rodrigues |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 12/21886-4 - Avaliação da frequência do polimorfismo fok1 do gene do receptor da Vitamina D (VDR) na etiologia da degeneração discal |
| Beneficiário: | Patricia Leme de Marchi |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |