Estudos de liberação e permeação de formulações contendo ácido cafeico.

Resumo

Phenolic compounds occur universally in the plant kingdom, and cinnamic acids make part of that group of organic compounds. The caffeic acid (CA) is one of those representatives, with powerful antioxidant activity and it induces collagen production, preventing premature aging of the skin. The classic emulsions are widely used by consumers because they provide a pleasant and refreshing sensory, however, preparations developed in the form of film or dried pellicle present as an alternative technology for its ease and safety during transportation. To overcome the skin barrier, micro and nanostructured systems have been developed to facilitate the delivery of substances, making them available to the tissue for a prolonged period of time without damage or toxicity. The objective of this study is to obtain the release profile, permeation and retention in vitro of the caffeic acid microparticles from the emulsion and film. Thus, chitosan microparticles containing caffeic acid will be obtained by spray drying and will be incorporated in an emulsion, and in a cosmetic preparation in film. Finally it will measure the release profile in vitro permeation and retention of microparticles of caffeic acid from the emulsion and film.Keywords: caffeic acid, microparticles, emulsion, Film, Cutaneous Permeation.