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INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar

Processo: 14/50928-2
Modalidade de apoio:Auxílio à Pesquisa - Temático
Vigência: 01 de julho de 2017 - 31 de dezembro de 2025
Área do conhecimento:Ciências da Saúde - Farmácia
Convênio/Acordo: CNPq - INCTs
Pesquisador responsável:Maria Vitória Lopes Badra Bentley
Beneficiário:Maria Vitória Lopes Badra Bentley
Instituição Sede: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brasil
Auxílios(s) vinculado(s):17/17075-4 - INCT 2014 - nanotecnologia farmacêutica: uma abordagem transdisciplinar - Proc. n. 2014/50928-2, NanoSight NS300, AP.EMU
17/17076-0 - INCT 2014 - nanotecnologia farmacêutica: uma abordagem transdisciplinar - Proc. n. 2014/50928-2, vitrocell system, AP.EMU
17/17078-3 - INCT 2014 - nanotecnologia farmacêutica: uma abordagem transdisciplinar - Proc. n. 2014/50928-2, microscópio de força atômica, AP.EMU
+ mais auxílios vinculados 17/17079-0 - INCT 2014 - nanotecnologia farmacêutica: uma abordagem transdisciplinar - Proc. n. 2014/50928-2, sistema automático testes em células de difusão, AP.EMU
17/17455-1 - INCT 2014 - nanotecnologia farmacêutica: uma abordagem transdisciplinar - Proc. n. 2014/50928-2, microscópio de fluorescência, AP.EMU
17/17456-8 - INCT 2014 - Nanotecnologia farmacêutica: uma abordagem transdisciplinar - Proc. n. 2014/50928-2, cromatógrafo líquido de ultra eficiência - UPLC, AP.EMU - menos auxílios vinculados
Bolsa(s) vinculada(s):23/14018-0 - Lipossomas funcionalizados para a otimização de liberação de enzimas na terapia de doenças lisossomais: caracterização por microscopia de força atômica com microfluídica e avaliação em plataforma Organ-on-a-chip, BP.TT
22/10086-9 - Nanodispersões de fase líquido-cristalina como sistema carreador de mRNA para administração intranasal de vacina gênica, BP.DR
22/01969-4 - Nanopartículas líquido-cristalinas multifuncionais para co-liberação de siRNAs e piperina no tratamento tópico do vitiligo: desenvolvimento, caracterização e estudos in vitro, BP.DR
+ mais bolsas vinculadas 18/23357-5 - Cocristais multicomponentes de Anti-Inflamatórios Não Esteróides (AINEs) e Inibidores de Bomba de Prótons (IBPs): desenvolvimento, caracterização e avaliação biológica in vitro e in vivo, BP.PD
19/10761-5 - Sistemas multifuncionais destinados à liberação cólon específica do bevacizumabe para o tratamento do Câncer Colorretal, BP.DR
19/19372-1 - Nanodispersões de fase líquida-cristalina como carreador de piperina para o tratamento tópico do vitiligo: desenvolvimento e avaliação, BP.IC
18/25377-3 - Avaliação do potencial de nanopartículas de sílica mesoporosas funcionalizadas com cetuximabe para veiculação de docetaxel no tratamento do câncer de próstata., BP.PD
18/23430-4 - Avaliação do potencial de lipossomas funcionalizados com bevacizumabe ou ácido hialurônico para incorporação de abiraterona no tratamento do câncer de próstata, BP.PD
18/23442-2 - Avaliação do potencial de lipossomas para co-encapsulação de anfotericina B e micafungina no tratamento de infecção sistêmica causada por Candida auris, BP.PD
18/08253-9 - Desenvolvimento e caracterização de nanodispersão de fase líquido-cristalina como sistema carreador multifuncional de siRNA TNF-alfa e Triptolida no tratamento tópico da psoríase, BP.MS - menos bolsas vinculadas
Assunto(s):Biologia  Nanotecnologia  Fármacos  Cosméticos  Toxicologia  Doenças parasitárias  Indústrias  Institutos de pesquisa 
Palavra(s)-Chave do Pesquisador:Biologia

Resumo

O INCT NANOFARMA representa uma importante estratégia de associação de competências já consolidadas na área de Nanotecnologia aplicada à medicamentos e cosméticos de grupos de pesquisa de várias universidades do Brasil, os quais atuam no desenvolvimento de projetos ligados à obtenção de nanocarreadores para diversas moléculas com atividade biológica, visando sua aplicação em terapias onde a Nanotecnologia pode agregar valores terapêuticos, avançar no desenvolvimento de técnicas e processos de obtenção, caracterização e avaliação destes produtos, bem como no entendimento dos aspectos químicos e biológicos (estudos mecanísticos de interação destes sistemas com tecidos/células e aspectos toxicológicos) envolvidos na obtenção e uso destes medicamentos. O INCT NANOFARMA, com a proposta de um INCT voltado à Nanotecnologia Farmacêutica no aspecto transdisciplinar da matéria, irá ainda agregar conhecimento técnico e ampliar as possibilidades de inovação das empresas associadas aos Parques Tecnológicos agregados às universidades envolvidas. Ele estará engajado nas propostas da Estratégia Nacional de Ciência, Tecnologia e Inovação, e desenvolverá, de forma articulada e integrada, pesquisa na fronteira do conhecimento, tecnologias para o setor público, atuará junto à sociedade na disseminação do conhecimento e formação de recursos humanos especializados, avançará nos aspectos regulatórios e deficientes da toxicologia e segurança de produtos de base nanotecnológica, viabilizará a geração de produtos inovadores baseados na Nanotecnologia, propiciado maior competitividade em acordos de cooperação nacional e internacional em áreas estratégicas da saúde, e maiores possibilidades de capacitação e fixação de recursos humanos, e finalmente, permitirá A gestão do INCT NANOFARMA será feita através do comitê gestor, o qual é composto por pesquisadores do INCT NANOFARMA abrangendo diferentes universidades e regiões do país, garantido, assim, abrangência institucional e nacional nas principais decisões deste INCT. As pesquisas e projetos vinculados ao INCT NANOFARMA serão desenvolvidos associados às plataformas de pesquisa para compreensão e entendimento dos diferentes aspectos envolvidos na ciência de medicamentos de base nanotecnológica. Os pesquisadores do INCT NANOFARMA através de seus projetos, equipe e laboratórios atuam de forma mais especificas em uma determinada plataforma, mas permeiam outras, mostrando a articulação do grupo nos principais temas de pesquisa da presente proposta. A equipe do INCT NANOFARMA destaca-se na produção científica qualificada nas áreas de abrangência da Nanotecnologia, caracterizando-se por ser uma equipe geradora de conhecimento transdisciplinar nesta área. Conta com profissionais de diferentes formações, a saber farmacêuticos (na sua maioria), químicos, engenheiros químicos e de produção, biólogos, físicos, biomédicos, etc. Sua produção científica resulta na publicação de cerca de 1213 trabalhos científicos em periódicos indexados nos últimos 05 anos. Os pesquisadores envolvidos apresentam Fator H relevantes considerando a área de atuação de pesquisa aplicada: cerca de 60% apresentam FH (ISI) entre 13 e 25 e 13% FH maiores ou igual a 20. Não se considera nesta abordagem os FH dos pesquisadores estrangeiros os quais chegam ao número de 166, evidenciando a excelência dos colaboradores estrangeiros que estão apoiando e está proposta. A formação de recursos humanos também é um destaque, com orientações concluídas de 787 alunos de iniciação científica, 586 de mestrado, 299 de doutorado e 88 pós-doutorados. Em andamento, os membros do INCT NANOFARMA estão contribuindo para a formação de 72 alunos de iniciação científica, 97 de mestrado, 151 de doutorado e 37 pesquisadores em pós-doutoramento. A qualidade dos trabalhos orientados é refletida por um fato de extrema relevância. A equipe do INCT NANOFARMA orientou 06 teses de doutorado que foram premiadas no Prêmio CAPES de Tese da área da Farmácia (05) e da área de Biotecnologia (01), destacando-se que de oito edições da área da Farmácia 05 premiações são de pesquisadores do INCT NANOFARMA. Com relação à contribuição tecnológica os membros do INCT NANOFARMA são inventores em 171 patentes junto ao INPI, sendo várias delas também depositada no exterior e já comercializadas pelo setor privado (Figura 3). As perspectivas de impacto para o projeto abrangem não apenas os aspectos técnicos/tecnológicos e científicos, mas também cultural, econômico, ambiental, com foco na formação de pessoas qualificadas em todos os níveis para compreender, analisar, interpretar, utilizar, desenvolver, pesquisar, produzir e controlar produtos farmacêuticos que utilizem nanotecnologias. O desenvolvimento do projeto refletirá em impacto científico e tecnológico para as instituições de pesquisa e pesquisadores envolvidos, ampliando laços de multidisciplinaridade e produtividade, levando ao fortalecimento de colaborações e ao intercâmbio de ideias. Este impacto será evidenciado em publicações voltadas à disseminação do conhecimento. Impactos econômicos são evidentes para o setor industrial a partir da aplicação da nanotecnologia. Além da pesquisa na fronteira do conhecimento e do potencial do de desenvolver produtos altamente inovadores e de alto valor agregado para o setor industrial, este Instituto poderá contribuir para o desenvolvimento de capacitação e inovação de interesse para o país para resolver problemas antigos de saúde pública, como as doenças parasitárias de grande impacto populacional sem resolução, utilizando-se a sua capacidade científica e tecnológica instalada nas universidades. O Instituto tem patentes depositadas (fase de PCT) envolvendo formulações nanoestruturadas que poderão ter a tecnologia repassada para indústrias do setor público ou privado. (AU)

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Publicações científicas (157)
(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)
FLAVIA RODRIGUES DA SILVA; MAYARA RODRIGUES BRANDÃO DE PAIVA; LAYS FERNANDA NUNES DOURADO; RUMMENIGGE OLIVEIRA SILVA; CAROLINA NUNES DA SILVA; BRUNA LOPES DA COSTA; CIBELE RODRIGUES TOLEDO; MARIA ELENA DE LIMA; ARMANDO DA SILVA-CUNHA. Intravitreal injection of the synthetic peptide LyeTx I b, derived from a spider toxin, into the rabbit eye is safe and prevents neovascularization in a chorioallantoic membrane model. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, . (14/50928-2)
SCHULTZE, EDUARDA; BUSS, JULIETI; CORADINI, KARINE; BEGNINI, KARINE RECH; GUTERRES, SILVIA S.; COLLARES, TIAGO; RUVER BECK, RUY CARLOS; POHLMANN, ADRIANA R.; SEIXAS, FABIANA KOMMLING. Tretinoin-loaded lipid-core nanocapsules overcome the triple-negative breast cancer cell resistance to tretinoin and show synergistic effect on cytotoxicity induced by doxorubicin and 5-fluororacil. BIOMEDICINE & PHARMACOTHERAPY, v. 96, p. 404-409, . (14/50928-2)
REMIAO, MARIANA H.; SEGATTO, NATALIA V.; POHLMANN, ADRIANA; GUTERRES, SILVIA S.; SEIXAS, FABIANA K.; COLLARES, TIAGO. The Potential of Nanotechnology in Medically Assisted Reproduction. FRONTIERS IN PHARMACOLOGY, v. 8, . (14/50928-2)
VICTORELLI, FRANCESCA DAMIANI; FIORAMONTI CALIXTO, GIOVANA MARIA; DOS SANTOS RAMOS, MATHEUS APARECIDO; BAUAB, TAIS MARIA; CHORILLI, MARLUS. Metronidazole-Loaded Polyethyleneimine and Chitosan-Based Liquid Crystalline System for Treatment of Staphylococcal Skin Infections. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v. 14, n. 1, p. 227-237, . (14/50928-2, 13/01565-1, 17/10016-2)
ROSA, JULIANA; SUZUKI, ISABELLA; KRAVICZ, MARCELO; CARON, ANGELO; PUPO, ANA VITORIA; GARCIA PRACA, FABIOLA; LOPES BADRA BENTLEY, MARIA VITORIA. Current Non-viral siRNA Delivery Systems as a Promising Treatment of Skin Diseases. CURRENT PHARMACEUTICAL DESIGN, v. 24, n. 23, p. 2644-2663, . (14/50928-2)
LAMAS DE SOUZA, SARAH OLIVEIRA; ANDRADE GUERRA, MARIA CAROLINA; DIAS HENEINE, LUIZ GUILHERME; DE OLIVEIRA, CAROLINA REIS; CUNHA JUNIOR, ARMANDO DA SILVA; FIALHO, SILVIA LIGORIO; OREFICE, RODRIGO LAMBERT. Biodegradable core-shell electrospun nanofibers containing bevacizumab to treat age-related macular degeneration. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 29, n. 11, . (14/50928-2)
DIAS, MARINA FRANCA; PINHEIRO DE FIGUEIREDO, BRUNA CAROLINE; TEIXEIRA-NETO, JULIA; ANDRADE GUERRA, MARIA CAROLINA; FIALHO, SILVIA LIGORIO; CUNHA, ARMANDO SILVA. In vivo evaluation of antitumoral and antiangiogenic effect of imiquimod-oaded polymeric nanoparticles. BIOMEDICINE & PHARMACOTHERAPY, v. 103, p. 1107-1114, . (14/50928-2)
MAGALHAES, MILENA C. R. S.; CASTRO, BRENDA F. M.; DE CASTRO, WHOCELY V.; BARROS, ANDRE L. B.; FERNANDES, RENATA S.; SILVA-CUNHA, ARMANDO; FIALHO, SILVIA L.. Permeability and in vivo distribution of poly(epsilon-caprolactone) nanoparticles loaded with zidovudine. JOURNAL OF NANOPARTICLE RESEARCH, v. 20, n. 7, . (14/50928-2)
CARVALHO, I. P. S.; MIRANDA, M. A.; SILVA, L. B.; CHRYSOSTOMO-MASSARO, T. N.; PASCHOAL, J. A. R.; BASTOS, J. K.; MARCATO, P. D.. IN VITRO Anticancer Activity and Physicochemical Properties of SOLANUM LYCOCARPUM Alkaloidic Extract Loaded in Natural Lipid-Based Nanoparticles. COLLOID AND INTERFACE SCIENCE COMMUNICATIONS, v. 28, p. 5-14, . (14/50928-2, 12/50762-1, 14/16727-0)
DA SILVA, FLAVIA RODRIGUES; BRANDAO DE PAIVA, MAYARA RODRIGUES; NUNES DOURADO, LAYS FERNANDA; SILVA, RUMMENIGGE OLIVEIRA; DA SILVA, CAROLINA NUNES; DA COSTA, BRUNA LOPES; TOLEDO, CIBELE RODRIGUES; DE LIMA, MARIA ELENA; DA SILVA-CUNHA, ARMANDO. Intravitreal injection of the synthetic peptide LyeTx I b, derived from a spider toxin, into the rabbit eye is safe and prevents neovascularization in a chorio-allantoic membrane model. Journal of Venomous Animals and Toxins including Tropical Diseases, v. 24, . (14/50928-2)
CALGAROTO, SELMA; FAURI, LUCAS E.; FRANK, LUIZA A.; PAESE, KARINA; GUTERRES, SILVIA S.; POHLMANN, ADRIANA R.. Chemical stability, mass loss and hydrolysis mechanism of sterile and non-sterile lipid-core nanocapsules: The influence of the molar mass of the polymer wall. REACTIVE & FUNCTIONAL POLYMERS, v. 133, p. 161-172, . (14/50928-2)
PIVETTA, THAIS P.; SILVA, LETICIA B.; KAWAKAMI, CAMILA M.; ARAUJO, MARGARETE M.; DEL LAMA, MARIA PERPETUA F. M.; NAAL, ROSE MARY Z. G.; MARIA-ENGLER, SILVYA S.; GASPAR, LORENA R.; MARCATO, PRISCYLA D.. Topical formulation of quercetin encapsulated in natural lipid nanocarriers: Evaluation of biological properties and phototoxic effect. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 53, . (12/50762-1, 16/07596-4, 14/50928-2, 13/24413-2, 08/57805-2)
SILVA RIBEIRO, MARCELA COELHO; DE MIRANDA, MARCELO COUTINHO; CUNHA, PRICILA DA SILVA; ANDRADE, GRACIELLE FERREIRA; FULGENCIO, GUSTAVO DE OLIVEIRA; GOMES, DAWIDSON ASSIS; FIALHO, SILVIA LIGORIO; PITTELLA, FREDERICO; CHARRUEAU, CHRISTINE; ESCRIOU, VIRGINIE; et al. Neuroprotective Effect of siRNA Entrapped in Hyaluronic Acid-Coated Lipoplexes by Intravitreal Administration. PHARMACEUTICS, v. 13, n. 6, . (14/50928-2)
APOLINARIO, ALEXSANDRA CONCEICAO; HAUSCHKE, LEON; NUNES, JESSICA RIBEIRO; LOURENCO, FELIPE REBELLO; LOPES, LUCIANA BIAGINI. Design of multifunctional ethosomes for topical fenretinide delivery and breast cancer chemoprevention. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 623, . (14/50928-2, 18/14375-0, 18/13877-1)
ALEXSANDRA CONCEIÇÃO APOLINÁRIO; GIOVANNA CASSONE SALATA; ARTHUR F. R. BIANCO; CLAUDIO FUKUMORI; LUCIANA BIAGINI LOPES. ABRINDO A CAIXA DE PANDORA DOS NANOMEDICAMENTOS: HÁ REALMENTE MUITO MAIS ‘ESPAÇO LÁ EMBAIXO’. Química Nova, v. 43, n. 2, p. 212-225, . (18/14375-0, 17/23213-0, 14/50928-2, 18/13877-1)
SILVESTRINI, ANA VITORIA PUPO; CARON, ANGELO LUIS; VIEGAS, JULIANA; PRACA, FABIOLA GARCIA; BENTLEY, MARIA VITORIA LOPES BADRA. Advances in lyotropic liquid crystal systems for skin drug delivery. Expert Opinion on Drug Delivery, v. 17, n. 12, p. 1781-1805, . (14/50928-2)
MOREIRA CASTRO, BRENDA FERNANDA; FULGENCIO, GUSTAVO DE OLIVEIRA; DOMINGOS, LUISA CANGUSSU; LACERDA COTTA, OLIVER ARAUJO; SILVA-CUNHA, ARMANDO; FIALHO, SILVIA LIGORIO. Positively charged polymeric nanoparticles improve ocular penetration of tacrolimus after topical administration. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 60, . (14/50928-2)
EMANUELLI, JULIANA; PAGNUSSAT, VIVIANE; KRIESER, KATHERINE; WILLIG, JULIA; BUFFON, ANDREIA; KANIS, LUIZ A.; BILATTO, STANLEY; CORREA, DANIEL SOUZA; MAITO, THAIS F.; GUTERRES, SILVIA S.; et al. Polycaprolactone and polycaprolactone triol blends to obtain a stable liquid nanotechnological formulation: synthesis, characterization and in vitro - in vivo taste masking evaluation. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, . (14/50928-2)
TAVARES, R. S. N.; TAO, THI PHUONG; MASCHMEYER, I; MARIA-ENGLER, S. S.; SCHAEFER-KORTING, M.; WINTER, A.; ZOSCHKE, C.; LAUSTER, R.; MARX, U.; GASPAR, L. R.. Toxicity of topically applied drugs beyond skin irritation: Static skin model vs. Two organs-on-a-chip. International Journal of Pharmaceutics, v. 589, . (14/50928-2)
FELIPPIM, ELISA C.; MARCATO, PRISCYLA D.; MAIA CAMPOS, PATRICIA MARIA BERARDO GONCALVES. Development of Photoprotective Formulations Containing Nanostructured Lipid Carriers: Sun Protection Factor, Physical-Mechanical and Sensorial Properties. AAPS PHARMSCITECH, v. 21, n. 8, . (14/50928-2)
DA SILVA, FLAVIA RODRIGUES; SILVA, RUMMENIGGE OLIVEIRA; DE CASTRO OLIVEIRA, HORTENCIA MACIEL; NUNES DOURADO, LAYS FERNANDA; DA COSTA, BRUNA LOPES; LIMA, BRUNO SANTOS; LIMA SANTOS, NAYARA GOMES; PALANCH REPEKE, CARLOS EDUARDO; MENEZES, GUSTAVO BATISTA; DE SOUZA ARAUJO, ADRIANO ANTUNES; et al. Gelatin-based membrane containing usnic acid-loaded liposomes: A new treatment strategy for corneal healing. BIOMEDICINE & PHARMACOTHERAPY, v. 130, . (14/50928-2)
MOJEIKO, GABRIELA; APOLINARIO, ALEXSANDRA CONCEICA; SALATA, GIOVANNA CASSONE; CHORILLI, MARLUS; LOPES, LUCIANA B.. Optimization of nanoemulsified systems containing lamellar phases for co-delivery of celecoxib and endoxifen to the skin aiming for breast cancer chemoprevention and treatment. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 646, p. 14-pg., . (19/26048-6, 18/14375-0, 19/00196-9, 18/13877-1, 14/50928-2)
AMARAL, VENANCIO A.; DE SOUZA, JULIANA FERREIRA; ALVES, THAIS F. R.; DE OLIVEIRA JUNIOR, JOSE M.; SEVERINO, PATRICIA; ARANHA, NORBERTO; SOUTO, ELIANA B.; CHAUD, MARCO V.. Psidium guajava L. phenolic compound-reinforced lamellar scaffold for tracheal tissue engineering. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v. N/A, p. 18-pg., . (14/50928-2)
SATO, MARIANA RILLO; OSHIRO-JUNIOR, JOAO AUGUSTO; RODERO, CAMILA FERNANDA; BONI, FERNANDA ISADORA; ARAUJO, VICTOR HUGO SOUSA; BAUAB, TAIS MARIA; NICHOLAS, DEAN; CALLAN, JOHN FRANCIS; CHORILLI, MARLUS. Enhancing Antifungal Treatment of Candida albicans with Hypericin-Loaded Nanostructured Lipid Carriers in Hydrogels: Characterization, In Vitro, and In Vivo Photodynamic Evaluation. PHARMACEUTICALS, v. 16, n. 8, p. 12-pg., . (18/17573-7, 16/11198-4, 14/50928-2, 19/10261-2, 19/17913-5)
CAMPOS, PATRICIA MAZUREKI; PRACA, FABIOLA GARCIA; MUSSI, SAMUEL VIDAL; FIGUEIREDO, SONIA APARECIDA; FANTINI, MARCIA CARVALHO DE ABREU; FONSECA, MARIA JOSE VIEIRA; TORCHILIN, VLADIMIR P.; BENTLEY, MARIA VITORIA LOPES BADRA. Liquid crystalline nanodispersion functionalized with cell-penetrating peptides improves skin penetration and anti-inflammatory effect of lipoic acid after in vivo skin exposure to UVB radiation. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v. 10, n. 6, p. 19-pg., . (14/50928-2)
FERREIRA, NATALIA N.; BONI, FERNANDA, I; BALTAZAR, FATIMA; GREMIAO, MARIA P. D.. Validation of an innovative analytical method for simultaneous quantification of alpha-cyano-4-hydroxycinnamic acid and the monoclonal antibody cetuximab using HPLC from PLGA-based nanoparticles. Journal of Pharmaceutical and Biomedical Analysis, v. 190, p. 10-pg., . (14/50928-2, 16/09671-3)
VIEGAS, JULIANA SANTOS ROSA; PRACA, FABIOLA GARCIA; KRAVICZ, MARCELO; BENTLEY, MARIA VITORIA LOPES BADRA. Therapeutic applications and delivery systems for triptolide. DRUG DELIVERY AND TRANSLATIONAL RESEARCH, v. 10, n. 6, SI, . (14/50928-2, 19/04448-2)
SOUZA, MAURICIO PALMEIRA CHAVES DE; SABIO, RAFAEL MIGUEL; RIBEIRO, TAIS DE CASSIA; SANTOS, ALINE MARTINS DOS; MENEGUIN, ANDREIA BAGLIOTTI; CHORILLI, MARLUS. Highlighting the impact of chitosan on the development of gastroretentive drug delivery systems. International Journal of Biological Macromolecules, v. 159, p. 804-822, . (14/50928-2)
SAITO, MAX S.; ZATTA, KELLY C.; SATHLER, PLINIO C.; FURTADO, PRISCILA S.; MIGUEL, NADIA C. O.; FRATTANI, FLAVIA S.; BERGER, MARKUS; LAVAYEN, VLADIMIR; POHLMANN, ADRIANA R.; GUTERRES, SILVIA S.. Therapeutic implementation in arterial thrombosis with pulmonary administration of fucoidan microparticles containing acetylsalicylic acid. International Journal of Pharmaceutics, v. 622, p. 11-pg., . (14/50928-2)
KRAVICZ, MARCELO H.; BALOGH, DEBORA T.; KAR, MRITYUNJOY; WEDEPOHL, STEFANIE; BENTLEY, MARIA VITORIA L. B.; CALDERON, MARCELO. Influence of Alkyl Chains of Modified Polysuccinimide-Based Polycationic Polymers on Polyplex Formation and Transfection. Macromolecular Bioscience, v. 19, n. 10, . (14/50928-2)
MIRANDA, MARIZA A.; MARCATO, PRISCYLA D.; CARVALHO, IVANA P. S.; SILVA, LETICIA B.; RIBEIRO, DIEGO L.; AMARAL, ROBSON; SWIECH, KAMILLA; BASTOS, JAIRO K.; PASCHOAL, JONAS A. R.; DOS REIS, RODOLFO B.; et al. Assessing the cytotoxic potential of glycoalkaloidic extract in nanoparticles against bladder cancer cells. Journal of Pharmacy and Pharmacology, v. 71, n. 10, . (14/50928-2, 15/14665-0)
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VICTORELLI, FRANCESCA DAMIANI; DE OLIVEIRA CARDOSO, VALERIA MARIA; FERREIRA, NATALIA NORONHA; FIORAMONTI CALIXTO, GIOVANA MARIA; FONTANA, CARLA RAQUEL; BALTAZAR, FATIMA; DAFLON GREMIAO, MARIA PALMIRA; CHORILLI, MARLUS. Chick embryo chorioallantoic membrane as a suitable in vivo model to evaluate drug delivery systems for cancer treatment: A review. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, v. 153, p. 273-284, . (14/50928-2, 19/07245-5, 18/04546-1, 13/01565-1, 16/09671-3, 15/21412-0, 16/06337-5, 17/10016-2, 17/23357-2)
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POUND-LANA, GWENAELLE E. N.; GARCIA, GIANI M.; TRINDADE, IZABEL C.; CAPELARI-OLIVEIRA, PATRICIA; PONTIFICE, THAIS GODINHO; VILELA, JOSE MARIO C.; ANDRADE, MARGARETH S.; NOTTELET, BENJAMIN; POSTACCHINI, BRUNA B.; MOSQUEIRA, VANESSA C. F.. Phthalocyanine photosensitizer in polyethylene glycol-block-poly(lactide-co-benzyl glycidyl ether) nanocarriers: Probing the contribution of aromatic donor-acceptor interactions in polymeric nanospheres. Materials Science & Engineering C-Materials for Biological Applications, v. 94, p. 220-233, . (14/50928-2)
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SHIKIDA, DANIELLE NISHIDA RAMOS; DALMOLIN, LUCIANA FACCO; FUMAGALLI, FERNANDO; EMERY, FLAVIO DA SILVA; LOPEZ, V, RENATA F.. Arginine-conjugated chitosan nanoparticles for topical arginine release in wounds. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 61, . (14/50928-2, 14/22451-7)
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BRUINSMANN, FRANCIELE ALINE; VAZ, GUSTAVO RICHTER; SOARES ALVES, ALINE DE CRISTO; AGUIRRE, TANIRA; POHLMANN, ADRIANA RAFFIN; GUTERRES, SILVIA STANISCUASKI; SONVICO, FABIO. Nasal Drug Delivery of Anticancer Drugs for the Treatment of Glioblastoma: Preclinical and Clinical Trials. Molecules, v. 24, n. 23, . (14/50928-2)
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FRANK, LUIZA ABRAHAO; GAZZI, R. P.; MELLO, P. A.; CHAVES, P.; PENA, F.; BECK, R. C. R.; BUFFON, A.; POHLMANN, A. R.; GUTERRES, SILVIA S.. Anti-HPV Nanoemulsified-Imiquimod: A New and Potent Formulation to Treat Cervical Cancer. AAPS PHARMSCITECH, v. 21, n. 2, . (14/50928-2)
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DOS SANTOS RAMOS, MATHEUS APARECIDO; DE TOLEDO, LUCIANI GASPAR; SPOSITO, LARISSA; MARENA, GABRIEL DAVI; DE LIMA, LAURA CAMINITTI; FORTUNATO, GIOVANNA CAPALDI; ARAUJO, VICTOR HUGO SOUSA; BAUAB, TAIS MARIA; CHORILLI, MARLUS. Nanotechnology-based lipid systems applied to resistant bacterial control: A review of their use in the past two decades. International Journal of Pharmaceutics, v. 603, . (18/23442-2, 14/50928-2)
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PORTAPILLA, GISELE BULHOES; PEREIRA, LUIZ MIGUEL; BRONZON DA COSTA, CASSIA MARIANA; PROVIDELLO, MAIARA VOLTARELLI; SAMPAIO OLIVEIRA, PEDRO ALEXANDRE; GOULART, AMANDA; ANCHIETA, NAIRA FERREIRA; WAINWRIGHT, MARK; LEITE BRAGA, GILBERTO UBIDA; DE ALBUQUERQUE, SERGIO. Phenothiazinium Dyes Are Active against Trypanosoma cruzi In Vitro. BIOMED RESEARCH INTERNATIONAL, v. 2019, p. 9-pg., . (14/50928-2)
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