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Redoxoma

Processo: 13/07937-8
Modalidade de apoio:Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Vigência: 01 de setembro de 2013 - 31 de agosto de 2025
Área do conhecimento:Ciências Biológicas - Bioquímica - Metabolismo e Bioenergética
Pesquisador responsável:Ohara Augusto
Beneficiário:Ohara Augusto
Instituição Sede: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brasil
Pesquisadores principais:
( Atuais )
Ana Maria da Costa Ferreira ; Carmen Fernandez ; Francisco Rafael Martins Laurindo ; Luis Eduardo Soares Netto ; Marisa Helena Gennari de Medeiros ; Mauricio da Silva Baptista ; Paolo Di Mascio ; Sayuri Miyamoto
Pesquisadores principais:
( Anteriores )
Alicia Juliana Kowaltowski
Pesquisadores associados:Alicia Juliana Kowaltowski ; Antonia Tavares Do Amaral ; Bayardo Baptista Torres ; Daniela Ramos Truzzi ; DANILO BILCHES MEDINAS ; Denise de Castro Fernandes ; Eduardo Alves de Almeida ; Fernanda Marques da Cunha ; Flavia Carla Meotti ; Graziella Eliza Ronsein ; Guilherme Andrade Marson ; Isaias Glezer ; João Paulo Tardivo ; José Carlos Toledo Junior ; Julio Cesar Batista Ferreira ; Lucia Rossetti Lopes ; Marcos Antonio de Oliveira ; Marilene Demasi ; Mario Henrique de Barros ; Pio Colepicolo Neto
Auxílios(s) vinculado(s):23/06807-5 - Desenvolvimento de uma unidade versátil de escaneamento 3D para detecção automatizada e resolvida no tempo de várias emissões características no Vis-NIR, AV.EXT
23/05863-9 - EMU concedido no processo 13/07937-8: sistema de cromatografia em fase líquida de alta eficiência, marca Shimadzu, modelo Prominence-i LC- 2050/LC-2060, AP.EMU
22/01430-8 - EMU concedido no processo 2013/07937-8: Liofilizador, AP.EMU
+ mais auxílios vinculados 22/00751-5 - EMU concedido no projeto 2013/07937-8: FPLC, AP.EMU
21/10771-0 - EMU concedido no processo 2013/07937-8: Espectrômetro de EPR, AP.EMU
21/03972-0 - EMU concedido no processo 2013/07937-8: Time Lapse, AP.EMU
21/01745-6 - EMU concedido no projeto 2013/07937-8: Leitora de Microplacas, AP.EMU
19/15632-9 - EMU concedido no projeto 2013/07937-8: leitora de microplacas, AP.EMU
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18/14871-7 - 22nd European Symposium on Quantitative Structure-Activity Relationships, AR.EXT
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16/50342-3 - Advanced EPR spectroscopy applied to mechanistic studies on metallodrugs-biomolecules interactions, AP.R SPRINT
16/12392-9 - 21st European Symposium on Quantitative Structure-Activity Relationship Where Molecular Simulations Meet Drug Discovery, AR.EXT - menos auxílios vinculados
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19/00813-8 - Modificações oxidativas da proteína dissulfeto isomerase e possíveis papéis em proteopatias, BP.IC
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17/09774-0 - Geração e detecção de oxigênio singlete em sistemas complexos para estudos de lesões celulares utilizando nanopartículas apresentando upconversion., BP.PD
17/12951-0 - A análise da construção do conteúdo de reações redox em livros didáticos da educação básica, BP.MS
16/24761-9 - Esclerose Lateral Amiotrófica: estudo dos mecanismos associados a efeitos da carnosina, BP.PD
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16/20864-8 - Papel de polifosfato no estado redox durante processos amiloidogênicos utilizando sensores fluorescentes geneticamente codificados, BE.PQ
16/06186-7 - Dinâmica Mitocondrial e transporte de Ca2+: Implicações Bioenergéticas, BE.PQ
16/16735-8 - Imobilização de potenciais metalofármacos em matrizes inorgânicas ou orgânicas para liberação modificada, BP.PD
16/11724-8 - Efeitos da restrição calórica sobre o proteassomo de leveduras Saccharomyces cerevisiae, BP.DR
16/18632-1 - Estudos funcionais de sistemas tiorredoxina de fungos: caracterização das especificidades enzimáticas, BP.IC
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16/08677-8 - Reflexos do PIBID na prática pedagógica de licenciandos em química envolvendo o conteúdo oxirredução, BP.DD
16/09242-5 - Suporte técnico para produção de proteínas recombinantes em larga escala, BP.TT
15/25776-7 - Mecanismos Moleculares do Particionamento Mitocondrial em Células de Mamífero., BP.PD
15/25923-0 - Modulação da calcificação vascular pela dissulfeto isomerase proteica (PDI): estudo em um novo modelo de camundongo transgênico, BP.PD
15/25898-5 - Danos por oxidação e alquilação em DNA em modelos celulares de Esclerose Lateral Amiotrófica e Xeroderma pigmentosu, BP.IC
15/25983-2 - Metabolismo redox eritrocitário: implicações para o uso de melatonina no tratamento de pessoas com anemia falciforme, BP.PD
15/13274-7 - Reações redox e livros didáticos: como esse conteúdo é apresentado e como os modelos de ensino são utilizados, BP.IC
15/01681-7 - Estudo de mecanismos e papel biológico de carnosina e compostos derivados, BP.DD
15/04942-6 - Mecanismo e cinética de formação de s-nitrosoproteínas a partir de dinitrosilo complexos de ferro associados a glutationa s-transferase (GST-DNIC), BP.IC
14/09334-1 - Papel da proteína dissulfeto isomerase (PDI) na ativação do EGFR e regulação da expressão e atividade da NADPH oxidase em células musculares lisas vasculares, BP.PD
14/14356-4 - Reações redox: uma proposta para desenvolver o conhecimento pedagógico do conteúdo, BP.DR
14/07593-0 - Investigação da relevância biológica de sistemas redutores de 1-Cys peroxirredoxinas de plantas, BP.PD
14/11556-2 - Cardiolipina em doenças neurodegenerativas: caracterização de produtos oxidados e de proteínas modificadas em um modelo de Esclerose Lateral Amiotrófica, BP.DD
14/09518-5 - Mecanismos de S-nitrosação de proteínas: cinética, mecanismo e implicações biológicas, BP.PD
14/05902-5 - Determinação das constantes cinéticas da redução de peroxirredoxinas por tiorredoxinas através de alterações de fluorescência em diferentes estados redox, BP.IC
13/17115-5 - Dissulfeto-isomerase proteica epi/pericelular: um novo regulador de adaptação biomecânica em células vasculares, BP.PD
13/16192-6 - Análise do papel da Thr44 de Tsa1 de Saccharomyces cerevisiae na catálise de hidroperóxidos, interação com Trx, oligomerização e processo de superoxidação, BP.IC
12/21722-1 - Caracterização estrutural e bioquímica de proteínas da família Ohr/OsmC: ênfase para a caracterização de uma proteína de Francisella tularensis envolvida em patogenicidade, BP.PD - menos bolsas vinculadas
Assunto(s):Antioxidantes  Biomarcadores  Radicais livres  Estresse oxidativo  Oxirredução  Cooperação técnica  Financiamento em saúde 
Palavra(s)-Chave do Pesquisador:Antioxidants | Biomarkers | Free Radicals | Oxidants | redox signaling | Thiol proteins | Metabolismo e Bioenergética
Publicação FAPESP:https://media.fapesp.br/bv/uploads/pdfs/Multidisciplinary_science_UgLePiV_34_35.pdf

Resumo

O estudo de processos redox tem alto potencial para elucidar mecanismos integrativos, devido à ubiquidade e potência de efeitos. Muitos estudos envolvem o papel de mecanismos redox em doenças. Porém, a complexidade deste campo aumentou com respeito a estruturas, estrutura-função, métodos, patologia molecular e sub-celular de proteínas redox, genômica, proteômica e metabolômica do estresse oxidativo. Assim, uma abordagem multidisciplinar se tornou essencial para avanços relevantes na área. Além disso, grupos emergentes têm dificuldade em realizar investigações relevantes e reeducar-se em novas habilidades. O principal objetivo do CEPID Redoxoma é promover colaborações integrativas, desenvolvimento sustentado e assistência a grupos emergentes. Nossa meta é realizar estudos que permitam o desenho e avaliação de novas estratégias antioxidantes de aplicabilidade clínica. Focalizaremos pontos críticos para superar limitações do conhecimento de processos redox: 1) geração e controle de espécies reativas de oxigênio (ROS) em sistemas biológicos; 2) reatividade química de ROS em ambientes biológicos e consequentes mudanças na estrutura e função de biomoléculas; 3) mecanismos eredes envolvidos nos processos de sinalização redox relevantes para doenças humanas; 4) aplicações diagnósticas e terapêuticas de processos redox. As estratégias propostas permitirão, em âmbito nacional, um coerente esforço para estudar questões-chave que preencham lacunas relevantes na área. Tais esforços serão estratégicos para promover integração disciplinar e de Instituições do Brasil, resultando em avanços que tenham impacto científico, educacional, ambiental e socioeconômico. (AU)

Matéria(s) publicada(s) na Revista Pesquisa FAPESP sobre o auxílio::
Bioquímicos detectan alteraciones en la retina asociadas a la ceguera en bebés prematuros 
Bioquímicos identificam alterações na retina associadas à cegueira em prematuros 
Un danger de plus du soleil 
Otro peligro del Sol 
Na hora do aperto 
A la hora de las dificultades 
Um perigo a mais do sol 
Otro peligro del Sol 
Matéria(s) publicada(s) no Pesquisa para Inovação FAPESP sobre o auxílio:
Startup desenvolve irradiadores UVC para descontaminação  
Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio:
Matéria(s) publicada(s) em Outras Mídias (0 total):
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Publicações científicas (441)
(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)
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MÉTODO DE IDENTIFICAÇÃO DE COMPOSTOS INIBIDORES DE ECTO-5`-NUCLEOTIDASE HUMANA (CD73) E USO DOS COMPOSTOS IDENTIFICADOS BR1020180071661 - Universidade de São Paulo (USP) . ANTONIA TAVARES DO AMARAL / ALEXANDER HENNING ULRICH / ARQUIMEDES CHEFFER / LUCAS GASPARELLO VIVIANI - 09 de abril de 2018

USO DE DITERPENOIDES ENT-CAURÂNOS EM ASSOCIAÇÃO A ANTIBIÓTICOS PARA INIBIÇÃO DE ENZIMAS PEROXIRREDOXINAS DE MICRORGANISMOS PARA O COMBATE DE INFECÇÕES MICROBIANAS BR1020200162454 - Universidade de São Paulo (USP) ; Universidade Estadual Julio de Mesquita Filho (UNESP) . GISELE MONTEIRO / Adalberto Pessoa Junior / ANA JÚLIA FERNANDES CARDOSO DE OLIVEIRA / BRUNA DEL BUSSO ZAMPIERI / CARLOS ABRUNHOSA TAIRUM JUNIOR / CARLOS ALEXANDRE BREYER / LUIS EDUARDO SOARES NETTO / MARCOS ANTONIO DE OLIVEIRA / MARCOS HIKARI TOYAMA / MELINA CARDOSO DOS SANTOS / ROLANDO IÉ / VANESSA DA COSTA ANDRADE - 10 de agosto de 2020