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CIBFar - Centro de Inovação em Biodiversidade e Fármacos

Processo: 13/07600-3
Modalidade de apoio:Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
Vigência: 01 de julho de 2013 - 30 de junho de 2025
Área do conhecimento:Ciências Biológicas - Biofísica
Pesquisador responsável:Glaucius Oliva
Beneficiário:Glaucius Oliva
Instituição Sede: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brasil
Pesquisadores principais:
Adriano Defini Andricopulo ; Carlos Roque Duarte Correia ; Fernando Antonio Santos Coelho ; Leila Maria Beltramini ; Luiz Carlos Dias ; Maysa Furlan ; Paulo Cézar Vieira ; Vanderlan da Silva Bolzani
Pesquisadores associados:Alberto Jose Cavalheiro ; Alessandro Silva Nascimento ; Andre Luis Berteli Ambrosio ; Angela Regina Araújo ; Arlene Gonçalves Corrêa ; Dulce Helena Siqueira Silva ; Eduardo Maffud Cilli ; Fabio Cardoso Cruz ; Ian Castro-Gamboa ; Ilana Lopes Baratella da Cunha Camargo ; Leonardo Luiz Gomes Ferreira ; Marcia Nasser Lopes ; Márcia Regina Cominetti ; Marilia Valli ; Mônica Tallarico Pupo ; Nelma Regina Segnini Bossolan ; Rafael Victorio Carvalho Guido
Auxílios(s) vinculado(s):23/09724-3 - EMU concedido no processo 13/07600-3: cromatógrafo preparativo Flash Selekt, AP.EMU
23/10718-8 - Evidências adicionais de uma simbiose emergente de abelha sem ferrão e levedura, PUB.ART
23/06024-0 - 266th ACS National Meeting & Exposition, AR.EXT
+ mais auxílios vinculados 23/01046-6 - Estruturação, organização e desenvolvimento de uma plataforma de busca de agentes antivirais contra os arbovírus causadores da febre Zika, febre Chikungunya e da febre Amarela utilizando os domínios enzimáticos de suas proteínas não-estruturais., AP.R
22/04089-5 - EMU concedido no processo 2013/07600-3: Vitrobot e ELSA cryo-transfer holder, AP.EMU
22/03494-3 - EMU concedido no processo 2013/07600-3: citometro, AP.EMU
21/13118-6 - EMU concedido no processo 2013/07600-3: Cromatógrafo Líquido de Alta Eficiência, AP.EMU
20/04602-9 - Desenvolvimento de antivirais para o tratamento da COVID-19, AP.R
19/13911-8 - 47th IUPAC World Chemistry Congress - 2019, AR.EXT
19/07606-8 - EMU concedido no processo 13/07600-3: Omnilog Phenotypic Miroarray, AP.EMU
19/07457-2 - EMU concedido no processo 2013/07600-3 "ROCKIMAGER 1000", AP.EMU
17/17920-6 - 10th European Conference on Marine Natural Products - ECMNP 2017, AR.EXT
17/05190-3 - Metabolomics 2017, AR.EXT
16/23279-9 - 5th Annual Conference of AnalytiX-2017, AR.EXT
16/13884-2 - EMU concedido no processo 2013/07600-3: MicroScale Thermophoresis (MST), AP.EMU
16/50009-2 - Greening sample preparation of complex matrices by using natural deep eutectic solvents (NADES) together with porous polymeric adsorbents for subsequent analyses by liquid chromatography (LC) and nuclear magnetic resonance (NMR), AP.R SPRINT
16/11312-1 - 9th Joint Natural Products Conference 2016, AR.EXT
15/08181-0 - American Society of Pharmacognosy 2015 Annual Meeting, AR.EXT
15/14968-2 - American Society of Pharmacognosy 2015 Annual Meeting, AR.EXT
15/06751-3 - Antitrypanosomal acetylene fatty acid derivatives from the seeds of Porcelia macrocarpa (Annonaceae), PUB.ART
14/50304-9 - Caracterização estereoquímica de ciclotideos de espécies do cerrado utilizando atividade óptica Raman, AP.R
14/15579-7 - 55th Annual American Society of Pharmacognosy Meeting & 14th Annual Oxford International Conference on the Science of Botanicals, AR.EXT
13/21599-8 - Estratégias para síntese de produtos naturais e análogos com atividade anti-cancerígena envolvendo reações multi-componentes organocatalisadas, AV.EXT
13/18375-0 - 61st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), AR.EXT - menos auxílios vinculados
Bolsa(s) vinculada(s):24/12642-1 - Avaliação de Propriedades Biológicas e Farmacocinéticas de Candidatas a Fármacos, BP.PD
23/17897-5 - Ecologia e toxinas killer de leveduras associadas às abelhas sem ferrão Scaptotrigona depilis e Tetragona clavipes, BP.PD
24/13840-1 - Determinação da estrutura in situ de glutaminase filamentosa por crio tomografia eletrônica de lamelas celulares, BP.PD
+ mais bolsas vinculadas 24/01273-5 - Estudo da quimiodiversidade fúngica e o seu potencial inibidor de proteases visando a descoberta de novos compostos antiparasitários e antivirais, BP.DR
24/06881-3 - Estudo químico da actinobactéria Streptomyces sp. CM17 associada à abelha sem ferrão Melipona scutellaris, BP.IC
23/12439-9 - Prospecção de Produtos Naturais Antibióticos em Microbiomas de Solo, BP.MS
23/10715-9 - Planejamento, síntese e otimização de compostos contendo o núcleo spirocromano para o tratamento da doença de Chagas, BP.MS
23/10388-8 - Otimização de compostos da série piridil diazepano para o tratamento da malária, BP.IC
22/13160-5 - Estudos integrados de biologia estrutural, química medicinal e aprendizado de máquina aplicados na descoberta de compostos líderes para Malária, BP.DD
23/10023-0 - Estudo de cinética enzimática e triagem de compostos como candidatos a inibidores da enzima piruvato quinase II (PKII) de Plasmodium falciparum, BP.IC
23/09022-9 - Planejamento, síntese e avaliação biológica de novos compostos químicos para quimioterapia., BP.PD
23/04660-7 - Caracterização funcional do complexo de replicação (DNA polimerase) do vírus Monkeypox, visando a busca por candidatos a fármacos antivirais, BP.MS
23/00025-5 - Reações de Heck-Matsuda enantiosseletivas autossustentadas via sais de diazônio gerados in situ a partir de anilinas ou nitroaril derivados em uma estratégia "one-pot", BP.PD
23/00874-2 - Acesso à quimiodiversidade de fungos: isolamento de inibidores de cisteíno proteases, BP.MS
22/15947-2 - Identificação e Otimização de Inibidores de Plasmodium falciparum como Candidatos a Fármacos para a Malaria, BP.PD
23/00242-6 - Avaliação de Propriedades Biológicas e Farmacocinéticas de Candidatas a Fármacos, BP.PD
22/16111-5 - Descoberta e desenvolvimento de candidatos antivirais contra a protease NS2B-NS3pro de Zika Vírus, BP.DD
22/10835-1 - Frutos brasileiros comestíveis ricos em proteases e suas explorações microbianas para identificação de novos constituintes bioativos, BP.PD
22/13110-8 - Otimização de Compostos Líderes para Tratamento de Doenças Parasitárias Tropicais em Colaboração com a Drugs for Neglected Diseases Initiative (DNDi), BP.IC
22/01266-3 - Descoberta de compostos com atividade antiviral contra a nsP2 protease do vírus Chikungunya (CHIKV), BP.MS
22/11106-3 - Busca por moléculas bioativas com ação inibitória na proteína não estrutural nsp13 de sars-cov-2, utilizando triagens enzimáticas e fragment screening, BP.PD
22/07493-1 - Síntese de ligantes da enzima NS3 helicase do Vírus Zika baseado em fragmentos, BP.IC
22/07984-5 - Centro de Pesquisa e Inovação em Biodiversidade e Fármacos, BP.TT
21/03977-1 - Descoberta de inibidores a partir de plantas do Cerrado brasileiro como candidatos a compostos líderes para a Malária, BP.DR
21/05646-2 - Engenharia metabólica aplicada à elucidação da via biossintética e produção sustentável de triterpenos quinonametídeos via expressão heteróloga em Saccharomyces cerevisiae, BP.DR
21/13544-5 - Planejamento, síntese e avaliação biológica de novos agentes antiparasitários contendo o motivo 1,2,4-oxadiazol em suas estruturas, BP.DD
21/14209-5 - Avaliação de Propriedades Farmacocinéticas e Biológicas de Candidatos a Fármacos, BP.PD
21/06317-2 - Investigação de derivados de quinazolinas com propriedades anticâncerâncer, BP.IC
21/06054-1 - Busca por candidatos a fármacos antivirais, tendo como alvo as RNA-polimerases dependentes de RNA (RdRp) do Alfavirus Chikungunya (NSP4) e do Betacoronavírus SARS-CoV-2 (NSP12), BP.PD
21/02777-9 - Descoberta de fármacos para o tratamento da Doença de Chagas, BP.PD
21/05629-0 - Centro de Pesquisa e Inovação em Biodiversidade e Farmácos - CIBFar, BP.TT
21/01706-0 - Triagem de compostos para a identificação de fármacos contra o vírus Chikungunya utilizando sistema replicon subgenômico, BP.IC
21/01686-0 - Triagem de compostos para a identificação de fármacos contra o vírus Zika utilizando sistema replicon subgenômico, BP.IC
20/16787-3 - Estudo químico de micro-organismos endofíticos isolados de Malouetia tamaquarina (Apocynaceae) contra Doenças Tropicais Negligenciadas, BP.IC
19/27790-8 - Desenvolvimento de ferramentas computacionais baseadas em aprendizado de máquina para a descoberta de novos candidatos a fármacos para a Malária, BP.PD
19/23175-7 - Formulação com extratos e frações de Casearia sylvestris para controle de biofilme cariogênico, BP.DR
19/24971-1 - Síntese, caracterização e avaliação da atividade de análogos do peptídeo (p-BthTX-I), BP.IC
19/26679-6 - Avaliação da atividade de produtos naturais e outros compostos contra bactérias multirresistentes e seus biofilmes, BP.TT
19/12632-8 - Sorocea bompladii: modelo vegetal para o isolamento de endófitos, visando a exploração racional da diversidade molecular, BP.IC
18/24344-4 - Otimização de compostos líderes para tratamento de doenças parasitárias tropicais em colaboração com a Drugs for Neglected Diseases Initiative (DNDi), BP.DR
19/09067-7 - Descobrindo o potencial dos metabólitos secundários de Malouetia tamaquarina (Apocynaceae) e seus endofíticos contra doenças tropicais neglegenciadas, BP.PD
18/25289-7 - Descoberta de novos ligantes bioativos com propriedades anticâncer, BP.DR
19/07603-9 - Exploração racional de Colletotrichum gloeosporiodes, visando à produção e isolamento de metabólitos bioativos e processos de scale-up, BP.IC
19/06587-0 - Centro de Pesquisa e Inovação em Biodiversidade e Fármacos (CIBFar), BP.TT
18/14153-7 - Investigação de alterações moleculares em pequenos grupos neurais seletivamente ativados (neuronal ensembles) do núcleo acumbens, que medeiam a incubação da fissura a cocaína induzida pelo ambiente, BP.DR
18/25600-4 - Descoberta e desenvolvimento de candidatos antivirais contra o vírus da Febre Amarela baseados na estrutura do complexo NS2B-NS3 protease, BP.DD
18/25773-6 - Descoberta de candidatos antivirais baseados na estrutura da enzima NS5 RNA polimerase RNA-dependente do vírus da febre amarela, BP.MS
19/06034-0 - Avaliação farmacocinética e de propriedades biológicas de candidatos a fármacos, BP.PD
19/05967-3 - Compreensão da função biológica de produtos naturais de Bases de Dados para o planejamento de compostos ativos para o tratamento de doenças infecciosas, BP.PD
18/23946-0 - Modelos preditivos para as fases dos fatores de estrutura de reflexões cêntricas em cristalografia de proteínas por aprendizado de máquina, BP.IC
19/01762-8 - Triagem de compostos naturais e sintéticos tendo como alvo proteínas de arbovírus, BP.TT
19/04788-8 - Avaliação da atividade de produtos naturais e outros compostos contra bactérias multirresistentes e seus biofilmes, BP.TT
18/23675-7 - Análise multiparamétrica do problema das fases em cristalografia de proteínas por aprendizagem profunda, BP.IC
18/17095-8 - Caracterização estrutural da proteína NSP4 RNA polimerase RNA-dependente do Vírus Chikungunya e busca por agentes antivirais, BP.DR
18/15887-4 - Otimização e elucidação da atividade antibacteriana de peptídeos catiônicos em patógenos multirresistentes, BP.DD
18/19574-0 - Biologia estrutural e desenvolvimento de fármacos contra a proteína NS5 do Vírus Zika, BP.DD
18/07287-7 - Descoberta de Derivados de Acridina e de Marinoquinolina como Inibidores de Plasmodium falciparum, BP.DR
18/05130-3 - Construção e caracterização de um sistema replicon sub-genômico do ZIKV para a descoberta de agentes antivirais., BP.PD
18/04896-2 - Estudo bioguiado de Talisia esculenta para a identificação de metabólitos secundários inibidores de glicação avançada, BP.IC
17/26679-0 - Derivados 4-quinolinonas como candidatos a fármacos antimaláricos: caracterização da atividade Antiplasmodial in vitro, in vivo e de modo de ação, BP.MS
17/16772-3 - Estudos estruturais e funcionais da enzima NS5 RNA-dependente RNA polimerase do vírus da febre amarela, BP.IC
17/23778-8 - Estratégias em quimioinformática para uma série de compostos antichagásicos, BP.IC
17/22661-0 - Estudos estruturais e funcionais do complexo NS2B-NS3 protease de febre amarela, BP.IC
17/17098-4 - Emprego de imageamento MALDI-MSI em tecidos foliares nodulados e não nodulados de Psychotria e Hybanthus: Localização, análise de ciclotídeos e sua relação com bactérias endossimbiontes, BP.PD
17/07229-4 - Caracterização estrutural das proteínas do vírus Chikungunya e busca por agentes antivirais, BP.PD
17/12326-9 - Orbitídeos de Croton antisyphiliticus e C. sphaerogynus (Euphorbiaceae), caracterização química-biológica e síntese: prospecção racional de peptídeos de baixo peso molecular com potencial antitumoral, BP.MS
17/15682-0 - Amidas de espécies de Piperaceae: estudos metabolômicos em matrizes naturais para bioprospecção de antimicrobianos, BP.IC
17/01287-2 - Triagem de compostos candidatos a novos medicamentos antitumorais por cultura celular tridimensional, BP.PD
17/04070-4 - Descoberta de derivados 4-quinolinonas como candidatos a composto líder para o desenvolvimento de novos antimaláricos, BP.IC
16/24714-0 - Estruturação de um banco de dados metabólicos para Casearia sylvestris usando LC-DAD-CAD-MS, BP.IC
16/24969-9 - Avaliação de compostos em patógenos bacterianos multirresistentes como parte do Centro de Pesquisa e Inovação em Biodiversidade e Fármacos - CIBFar, BP.IC
16/19712-9 - Caracterização estrutural das proteínas do vírus Zika e busca por agentes antivirais, BP.PD
16/17153-2 - Biologia estrutural e desenvolvimento de fármacos contra a proteína NS5 do vírus Zika, BP.DD
16/09235-9 - Fingerprinting metabólico (perfil cromatográfico) por LC-DAD-MS para controle de qualidade de drogas vegetais de espécies de Erythrina: desenvolvimento e validação de método, BP.MS
16/16402-9 - Centro de pesquisa e inovação em biodiversidade e fármacos., BP.TT
16/09772-4 - Estudos de biologia estrutural e química medicinal para a descoberta de inibidores da enzima enolase de Plasmodium falciparum, BP.MS
16/06499-5 - Estudos cristalográficos de complexos da enzima cruzaína de T.cruzi com inibidores, BP.IC
16/04004-9 - Exploração do potencial químico e de biotransformação do fungo Rhinocladiella similis na busca por compostos de interesse biológico, BP.IC
15/23244-8 - Desenvolvimento de novos peptídeos e bioconjugados com atividade contra infecção por Zika Vírus, BP.DR
15/25175-3 - Clonagem e caracterização das oxidorredutases do tipo citocromo P450 de Maytenus ilicifolia e seu efeito no aumento da produção de triterpenos quinonametídeos por expressão heteróloga em Saccharomyces ceravisiae, BP.PD
15/19495-5 - Síntese de compostos para o tratamento da Doença de Chagas no âmbito do CEPID/FAPESP/DNDi, BP.PD
15/18192-9 - Descoberta e Desenvolvimento de Fármacos Antimaláricos: Biologia Estrutural, Química Medicinal e Parasitologia, BP.PD
15/23095-2 - Síntese e caracterização de bioconjugados peptídicos com atividade antitumoral, BP.IC
15/21272-4 - Estudos Computacionais da Enzima N-Miristoiltransferase de Plasmodium falciparum e seus Inibidores como Candidatos a Agentes Antimaláricos, BP.MS
15/09533-7 - Ciclopeptídeos de Plantas de Ambientes Extremos (Bioma Caatinga): Caracterização, Função, Síntese e Avaliação do Potencial Antitumoral e Imunossupressor, BP.PD
15/11339-4 - Análise comparativa de alquilresorcinóis em cultivares de cana-de-açúcar e avaliação de eventual efeito protetor frente a patógenos fúngicos, BP.IC
14/26313-8 - Descoberta e Planejamento de Inibidores de Enolase de Plasmodium falciparum como Novos Agentes Antimaláricos, BP.PD
14/15145-7 - Estudos estruturais da enzima topoisomerase II mitocondrial de tripanossomatídeos, BP.PD
14/19362-2 - Aplicação da biotecnologia na avaliação da interação planta-microrganismo para a produção de metabólitos secundários em Peritassa campestris e seus endófitos, BP.PD
14/21567-1 - Estudo de micro-organismos isolados da rizosfera de Senna spectabilis visando a detecção de metabólitos bioativos, BP.IC
14/05538-1 - Síntese, caracterização, estudo do mecanismo de ação e análise de métodos de liberação do peptídeo pBthTX-I, nas formas monoméricas e diméricas, BP.PD
14/14067-2 - Prospecção da rota de anabolismo dos congêneres quinonametídeo de Maytenus spp. (Celastraceae) em exemplares biogeograficamente distintos, BP.PD
14/17931-0 - Avaliação da atividade de produtos naturais contra bactérias multirresistentes e seus biofilmes., BP.TT
14/02282-6 - Estudo da relação estrutura-atividade de alcalóides derivados da Pilocarpus microphyllus (Rutaceae) com ação contra Schistosoma mansoni, BP.PD
14/05935-0 - Co-cultura de micro-organismos isolados da rizosfera de Senna spectabilis visando a produção de metabólitos bioativos, BP.DD
14/02738-0 - Documentação química de espécies do gênero Casearia (Salicaceae) de importância ecológica, econômica e medicinal, BP.IC
14/00326-6 - Caracterização química de Ficus guaranítica (Moraceae): prospecção de compostos com interesse econômico e avaliação de atividades biológicas de interesse terapêutico, BP.IC
13/15306-8 - Estudos sobre a biossíntese dos triterpenos quinonametídeos por engenharia metabólica: avaliação do fluxo metabólico micro- e macromolecular do sistema heterólogo por técnicas metabolômicas e proteômicas., BP.PD
13/25658-9 - Planejamento e Desenvolvimento de Candidatos a Fármacos para a Doença de Chagas, BP.PD
13/24952-0 - Padrões da emergência de enterococci e staphylococci multiresistentes no Brasil e busca por novos fármacos, BP.PD
13/15086-8 - Aplicações da metabolômica e proteômica na busca por novas substâncias biologicamente ativas em espécies da família Malpighiaceae, BP.PD
13/16807-0 - Síntese de Compostos para o Tratamento da Doença de Chagas no Âmbito do CEPID-FAPESP/DNDi, BP.PD
13/18329-9 - "Avaliação In Vitro de Propriedades Citotóxicas e Farmacocinéticas de Compounds Bioativos de Origem Natural e Sintética", BP.TT
13/10933-4 - Aplicação de ferramentas biotecnológicas em Streptomyces olindensis para a obtenção de novos produtos naturais com potencial farmacêutico, BP.PD
13/03493-8 - Potencial de extratos brutos, óleo essencial e compostos isolados obtidos de Tagetes patula L. (Asteraceae) como antiparasitário botânico contra Rhipicephalus (Boophilus) microplus, Haemonchus contortus e Cimex lectularis, BP.PD
11/01544-9 - Análise proteômica com enfoque na enzima oxidoredutase do tipo P450 em raízes de plantas jovens e adultas de Maytenus ilicifolia (Celastraceae), BP.PD
11/10379-1 - CLONAGEM E CARACTERIZAÇÃO DE OXIDOESQUALENO CICLASES DE Maytenus ilicifolia Mart. ex Reissek, BP.PD
11/01003-8 - Estudos proteômicos em Peperomia obtusifolia (Piperaceae), BP.PD
11/03017-6 - Produtos naturais oriundos de plantas do Cerrado e Mata Atlântica, modelos potenciais e úteis para identificar protótipos com ação oxidante em neutrófilos e enzima mieloperoxidase (MPO), BP.PD - menos bolsas vinculadas
Assunto(s):Biodiversidade  Planejamento de fármacos  Fármacos  Produtos naturais  Síntese orgânica  Bioensaio  Financiamento em saúde 
Palavra(s)-Chave do Pesquisador:Bioprospecção | Ensaio biológico | inibidor | Planejamento de Fármacos | Produtos Naturais | Síntese Orgânica | Outra Subárea Biofísica
Publicação FAPESP:https://media.fapesp.br/bv/uploads/pdfs/Multidisciplinary_science_N0zamCM_16_17.pdf

Resumo

O Centro de Inovação em Biodiversidade e Fármacos (CIBFar) é uma iniciativa resultante de projetos de pesquisa colaborativos, envolvendo: (i) Laboratório de Química Medicinal e Computacional (LQMC) e Biofísica Molecular - IFSC - USP, (II) Núcleo de Bioensaios, Biossíntese e Eco Fisiologia de Produtos Naturais (NUBBE) – IQ - UNESP, (III) Laboratórios de Síntese Orgânica - IQ - UNICAMP, (iv) Laboratórios de Produtos Naturais e Síntese Orgânica - DQ - UFSCar, e (v) Laboratório de Produtos Naturais - FCFRP - USP. O objetivo principal desse Centro é a realização de ciência básica e aplicada, bem como o desenvolvimento tecnológico em todas as áreas de biodiversidade e de descoberta de fármacos com base em pesquisas que utilizam o estado da arte da química de produtos naturais, química orgânica sintética, biologia molecular e estrutural, bioquímica, química medicinal, planejamento de fármacos e ensaios farmacológicos. Os objetivos específicos são a bioprospecção da flora brasileira para a identificação de compostos com um amplo espectro de atividades biológicas (antiparasitária, antibacteriana, anticâncer); seleção de compostos bioativos promissores para síntese orgânica e estudos das relações entre a estrutura e atividade (SAR, QSAR); uso de estratégias de planejamento de fármacos baseado na estrutura do receptor e do ligante (SBDD e LBDD, respectivamente); abordagens para otimização de compostos-líderes; estudos pré-clínicos in vitro e in vivo para a avaliação e otimização de compostos-líderes, e estudos de toxicologia e farmacocinética. O objetivo final é o desenvolvimento de novos candidatos a fármacos com elevado potencial de inovação para desenvolvimento clínico. Para tanto, o CIBFar se baseia não apenas nas competências e conhecimentos científicos sólidos em todas as áreas de interesse, mas também em uma estrutura organizada para a integração das abordagens modernas em biodiversidade e descoberta de fármacos. O CIBFar tem como principal característica a infraestrutura bem estabelecida em termos de competências para o apoio técnico, financeiro, educação tecnológica e gestão executiva (adquirida nos últimos 11 anos como um dos CEPID-FAPESP). A integração máxima com o setor produtivo será realizada para identificação de oportunidades e definição de metas. No aspecto educacional, o Centro conta com a significativa experiência adquirida ao longo de uma década, em educação e disseminação do conhecimento realizada no CEPID-FAPESP. (AU)

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Publicações científicas (396)
(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)
SUELEM D. RAMALHO; MERI EMILI F. PINTO; RENATA K. ANDRICOPULO; PAULO R. S. SANCHES; EDILBERTO R. SILVEIRA; EDUARDO M. CILLI; ADRIANO D. ANDRICOPULO; VANDERLAN S. BOLZANI. Linear Peptide Analogues from Jatropha’s Orbitides Promote Migration of Human Neonatal Foreskin Fibroblasts in vitro and Collagen Deposition. Journal of the Brazilian Chemical Society, v. 30, n. 10, p. 2153-2161, . (17/17098-4, 15/09533-7, 10/52327-5, 13/07600-3)
MAIARA S. BORGES; CAROLINA R. BIASETTO; VANESSA M. CHAPLA; SAMAD N. EBRAHIMI; MAYRA F. COSTA; VANDERLAN S. BOLZANI; ANGELA R. ARAUJO. Assessment of Novel C-4 Methylated Tetraketide by HPLC-SPE-TT in Saccharicola sp., an Endophytic Fungus in Eugenia jambolana Lam.. Journal of the Brazilian Chemical Society, v. 30, n. 3, p. 522-527, . (14/50926-0, 13/07600-3)
JULIANA R. GUBIANI; HELDER L. TELES; GERALDO H. SILVA; MARIA CLÁUDIA M. YOUNG; JOSÉ O. PEREIRA; VANDERLAN S. BOLZANI; ANGELA R. ARAUJO. CYCLO-(TRP-PHE) DIKETOPIPERAZINES FROM THE ENDOPHYTIC FUNGUS Aspergillus versicolor ISOLATED FROM Piper aduncum#. Química Nova, v. 40, n. 2, p. 138-142, . (13/07600-3)
DANIELE RODRIGUES DE LIMA; MARIA GLEIZIANE DE ARAÚJO FRANCA; FÁTIMA DE CÁSSIA EVANGELISTA DE OLIVEIRA; CLÁUDIA DO Ó PESSOA; ALBERTO JOSÉ CAVALHEIRO; MARIA GORETTI DE VASCONCELOS SILVA. METABOLIC PROFILING AND CYTOTOXIC ACTIVITY OF METHANOL EXTRACTS FROM CHAMAECRISTA DUCKEANA (P. BEZERRA & A. FERN.) H. S. IRWIN & BARNEBY (LEGUMINOSAE, CAESALPINIOIDEAE). Química Nova, v. 45, n. 7, p. 803-806, . (13/07600-3, 14/50926-0)
MARTINEZ, PABLO D. G.; KRAKE, SUSANN H.; POGGI, MAITIA L.; CAMPBELL, SIMON F.; WILLIS, PAUL A.; DIAS, LUIZ C.. 2,3,8-Trisubstituted Quinolines with Antimalarial Activity. Anais da Academia Brasileira de Ciências, v. 90, n. 2, p. 1215-1231, . (15/50655-9, 13/07600-3)
CORREIA, JOSE TIAGO M.; ACCONCIA, LAIS V.; COELHO, FERNANDO. Studies on Pumiliotoxin A Alkaloids: An Approach to Preparing the Indolizidinic Core by Intramolecular Diastereoselective N-Heterocyclic Carbene Catalyzed Benzoin Reaction. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, n. 11, p. 1972-1976, . (13/24386-5, 13/10449-5, 12/21809-0, 13/07600-3)
BATISTA, ANDREA N. L.; BATISTA, JR., JOAO M.; ASHTON, LORNA; BOLZANI, VANDERLAN S.; FURLAN, MAYSA; BLANCH, EWAN W.. Investigation of DMSO-Induced Conformational Transitions in Human Serum Albumin Using Two-Dimensional Raman Optical Activity Spectroscopy. Chirality, v. 26, n. 9, SI, p. 497-501, . (12/16484-4, 12/13739-1, 13/07600-3)
FERNANDES, DANIARA C.; SIMONI, DEBORAH DE ALENCAR; RODRIGUES, JR., MANUEL T.; SANTOS, MARILIA S.; COELHO, FERNANDO. Crystal structure of 3-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydrocyclopenta[b]indole-2-car boxylic acid. ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, v. 71, n. 6, p. O395-U248, . (09/51602-5, 13/07600-3)
ARDILA, JORGE ARMANDO; FUNARI, CRISTIANO SOLEO; ANDRADE, ANDRE MARQUES; CAVALHEIRO, ALBERTO JOSE; CARNEIRO, RENATO LAJARIM. Cluster analysis of commercial samples of Bauhinia spp. using HPLC-UV/PDA and MCR-ALS/PCA without peak alignment procedure. Phytochemical Analysis, v. 26, n. 5, p. 367-373, . (10/52327-5, 13/07600-3, 12/15844-7, 10/16520-5)
CHAGAS, FERNANDA O.; RUZZINI, ANTONIO C.; BACHA, V, LARISSA; SAMBORSKYY, MARKYIAN; CONTI, RAPHAEL; PESSOTTI, RITA C.; DE OLIVEIRA, LUCIANA G.; CLARDY, JON; PUPO, MONICA T.. Genome Sequence of Streptomyces sp. Strain RTd22, an Endophyte of the Mexican Sunflower. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 4, n. 4, . (13/07600-3, 08/09540-0, 13/50954-0, 09/17695-6, 08/00812-7, 11/06209-3, 11/12910-6, 11/11703-7)
RAMALHO, SUELEM D.; PINTO, MERI EMILI F.; ANDRICOPULO, RENATA K.; SANCHES, PAULO R. S.; SILVEIRA, EDILBERTO R.; CILLI, EDUARDO M.; ANDRICOPULO, ADRIANO D.; BOLZANI, VANDERLAN S.. Linear Peptide Analogues from Jatropha's Orbitides Promote Migration of Human Neonatal Foreskin Fibroblasts in vitro and Collagen Deposition. Journal of the Brazilian Chemical Society, v. 30, n. 10, SI, p. 2153-2161, . (15/09533-7, 17/17098-4, 13/07600-3, 10/52327-5)
FERREIRA SANTOS, NATACHA CARVALHO; VALLI, MARILIA; BOLZANI, VANDERLAN DA SILVA. A brief overview on Brazilian women in chemistry. Pure and Applied Chemistry, v. 91, n. 4, SI, p. 743-749, . (14/50926-0, 13/07600-3)
LUCZYWO, AYELEN; GONZALEZ, LUCIA G.; AGUIAR, ANNA C. C.; OLIVEIRA DE SOUZA, JULIANA; SOUZA, GUILHERME E.; OLIVA, GLAUCIUS; AGUILAR, LUIS F.; CASAL, JUAN J.; GUIDO, RAFAEL V. C.; ASIS, SILVIA E.; et al. 3-aryl-indolinones derivatives as antiplasmodial agents: synthesis, biological activity and computational analysis. NATURAL PRODUCT RESEARCH, . (18/07287-7, 17/26679-0, 13/07600-3)
RODRIGUES JR, MANOEL T.; SANTOS, HUGO; ZEOLY, LUCAS A.; SIMONI, DEBORAH A.; MOYANO, ALBERT; COELHO, FERNANDO. Preparation of tetrahydro-1H-xanthen-1-one and chromen-1-one derivatives via a Morita-Baylis-Hillman/oxa-Michael/elimination cascade. ARKIVOC, n. 2, p. 77+, . (13/07600-3, 15/09205-0, 18/02611-0, 17/02364-0)
NUNES, WILHAN DONIZETE GONCALVES; RUSSO, HELENA MANNOCHIO; BOLZANI, VANDERLAN DA SILVA; CAIRES, FLAVIO JUNIOR. Thermal characterization and compounds identification of commercialStevia rebaudianaBertoni sweeteners and thermal degradation products at high temperatures by TG-DSC, IR and LC-MS/MS. JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, . (18/24378-6, 14/50926-0, 13/07600-3, 16/16970-7)
DE SOUZA, ANACLETO S.; FERREIRA, LEONARDO L. G.; DE OLIVEIRA, ALDO S.; ANDRICOPULO, ADRIANO D.. Quantitative Structure-Activity Relationships for Structurally Diverse Chemotypes Having Anti-Trypanosoma cruzi Activity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 11, . (13/07600-3)
OSHIRO-JUNIOR, JOAO AUGUSTO; BARROS, RAFAELA MORENO; DA SILVA, CAMILA GARCIA; DE SOUZA, CAROLINE CORDEIRO; SCARDUELI, CASSIO ROCHA; MARCANTONIO, CAMILA CHIERICI; DA SILVA SACHES, PAULO RICARDO; MENDES, LARISSA; CILLI, EDUARDO MAFFUD; CHIERICI MARCANTONIO, ROSEMARY ADRIANA; et al. In vivo effectiveness of hybrid membranes with osteogenic growth peptide for bone regeneration. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, . (13/07600-3)
OLIVEIRA, CAIO C.; DUARTE CORREIA, CARLOS ROQUE. Enantioselective Heck-Matsuda Reactions: From Curiosity to a Game-Changing Methodology. CHEMICAL RECORD, . (13/07600-3, 14/25770-6, 18/01669-5)
DE FREITAS, LARISSA; VALLI, MARILIA; DAMETTO, ALESSANDRA C.; PENNACCHI, PAULA C.; ANDRICOPULO, ADRIANO D.; MARIA-ENGLER, SILVYA S.; BOLZANI, VANDERLAN S.. Advanced Glycation End Product Inhibition by Alkaloids from Ocotea paranapiacabensis for the Prevention of Skin Aging. Journal of Natural Products, v. 83, n. 3, SI, p. 649-656, . (14/50926-0, 19/05967-3, 13/07600-3)
DANUELLO, AMANDA; DE CASTRO, ROGERIO CARDOSO; PILON, ALAN CESAR; PIRES BUENO, PAULA CAROLINA; PIVATTO, MARCOS; VIEIRA JUNIOR, GERARDO MAGELA; CARVALHO, FLAVIO ALEXANDRE; ODA, FERNANDO BOMBARDA; PEREZ, CONSUELO JAVIERA; LOPES, NORBERTO PEPORINE; et al. Fragmentation study of clerodane diterpenes from Casearia species by tandem mass spectrometry (quadrupole time-of-flight and ion trap). RAPID COMMUNICATIONS IN MASS SPECTROMETRY, v. 34, n. 3, SI, . (11/21440-3, 16/13292-8, 17/19702-6, 13/07600-3, 14/50926-0)
MONTEIRO, JULIA L.; MOREIRA, NATALIA M.; DOS SANTOS, DEBORAH A.; PAIXAO, MARCIO W.; CORREA, ARLENE G.. Step economy strategy for the synthesis of amphoteric aminoaldehydes, key intermediates for reduced hydantoins. Pure and Applied Chemistry, v. 90, n. 1, p. 121-132, . (12/07284-1, 15/17141-1, 14/50249-8, 13/07600-3)
PALUDO, CAMILA R.; MENEZES, CRISTIANO; SILVA-JUNIOR, EDUARDO A.; VOLLET-NETO, AYRTON; ANDRADE-DOMINGUEZ, ANDRES; PISHCHANY, GLEB; KHADEMPOUR, LILY; DO NASCIMENTO, FABIO S.; CURRIE, CAMERON R.; KOLTER, ROBERTO; et al. Stingless Bee Larvae Require Fungal Steroid to Pupate. SCIENTIFIC REPORTS, v. 8, . (12/22487-6, 12/24204-1, 13/07600-3, 13/50954-0, 13/04092-7, 14/23532-0)
SILVA, ALLAN R.; POLO, ELLEN C.; MARTINS, NELSON C.; CORREIA, CARLOS ROQUE D.. Enantioselective Oxy-Heck-Matsuda Arylations: Expeditious Synthesis of Dihydrobenzofuran Systems and Total Synthesis of the Neolignan (-)-Conocarpan. ADVANCED SYNTHESIS & CATALYSIS, v. 360, n. 2, p. 346-365, . (13/25886-1, 13/17083-6, 13/07600-3, 14/25770-6)
SANCHES POLITI, FLAVIO AUGUSTO; FANTATTO, RAFAELA REGINA; DA SILVA, ALEXANDER ALVES; MORO, ISABELA JACOB; SAMPIERI, BRUNO RODRIGUES; CAMARGO-MATHIAS, MARIA IZABEL; FIGUEIREDO, AMANDA; DE SOUZA CHAGAS, ANA CAROLINA; FURLAN, MAYSA. Evaluation of Tagetes patula (Asteraceae) as an ecological alternative in the search for natural control of the cattle tick Rhipicephalus (Boophilus) microplus (Acari: Ixodidae). Experimental and Applied Acarology, v. 77, n. 4, p. 601-618, . (13/07600-3, 13/03493-8)
SILVA, JULIANA DE OLIVEIRA; ANGNES, RICARDO A.; MENEZES DA SILVA, VITOR H.; SERVILHA, BRUNO M.; ADEEL, MUHAMMAD; BRAGA, ATAUALPA A. C.; APONICK, AARON; CORREIA, CARLOS ROQUE D.. Intermolecular Noncovalent Hydroxy-Directed Enantioselective Heck Desymmetrization of Cyclopentenol: Computationally Driven Synthesis of Highly Functionalized cis-4-Arylcyclopentenol Scaffolds. Journal of Organic Chemistry, v. 81, n. 5, p. 2010-2018, . (13/04813-6, 13/00544-0, 15/01491-3, 11/23832-6, 13/07600-3)
PILON, ALAN CESAR; NETO, FAUSTO CARNEVALE; FREIRE, RAFAEL TEIXEIRA; CARDOSO, PATRICIA; CARNEIRO, RENATO LAJARIM; BOLZANI, VANDERLAN DA SILVA; CASTRO-GAMBOA, IAN. Partial least squares model and design of experiments toward the analysis of the metabolome of Jatropha gossypifolia leaves: Extraction and chromatographic fingerprint optimization. JOURNAL OF SEPARATION SCIENCE, v. 39, n. 6, p. 1023-1030, . (10/17935-4, 13/07600-3, 11/50816-1)
SOUZA-MOREIRA, TATIANA M.; ALVES, THAS B.; PINHEIRO, KARINA A.; FELIPPE, LIDIANE G.; DE LIMA, GUSTAVO M. A.; WATANABE, TATIANA F.; BARBOSA, CRISTINA C.; SANTOS, VANIA A. F. F. M.; LOPES, NORBERTO P.; VALENTINI, SANDRO R.; et al. Friedelin Synthase from Maytenus ilicifolia: Leucine 482 Plays an Essential Role in the Production of the Most Rearranged Pentacyclic Triterpene. SCIENTIFIC REPORTS, v. 6, . (12/21005-8, 13/07600-3, 13/15306-8, 14/03819-3, 11/10379-1, 12/09584-2)
CHAGAS, FERNANDA O.; DIAS, LUIS G.; PUPO, MONICA T.. New perylenequinone derivatives from the endophytic fungus Alternaria tenuissima SS77. Tetrahedron Letters, v. 57, n. 29, p. 3185-3189, . (08/09540-0, 09/17695-6, 13/07600-3, 13/08166-5)
COSTA, FERNANDA CRISTINA; FRANCISCO, AMANDA FORTES; JAYAWARDHANA, SHIROMANI; CALDERANO, SIMONE GUEDES; LEWIS, MICHAEL D.; OLMO, FRANCISCO; BENEKE, TOM; GLUENZ, EVA; SUNTER, JACK; DEAN, SAMUEL; et al. Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping. PLoS Neglected Tropical Diseases, v. 12, n. 4, . (16/21283-9, 13/07600-3, 16/08958-7)
DIAS, LUIZ C.; POLO, ELLEN C.. Nhatrangin A: Total Syntheses of the Proposed Structure and Six of Its Diastereoisomers. Journal of Organic Chemistry, v. 82, n. 8, p. 4072-4112, . (11/06722-2, 12/02230-0, 13/07600-3)
BATISTA, ANDREA N. L.; DOS SANTOS-PINTO, JOSE ROBERTO A.; BATISTA, JR., JOAO M.; SOUZA-MOREIRA, TATIANA M.; SANTONI, MARIANA M.; ZANELLI, CLESLEI F.; KATO, MASSUO J.; LOPEZ, SILVIA N.; PALMA, MARIO S.; FURLAN, MAYSA. The Combined Use of Proteomics and Transcriptomics Reveals a Complex Secondary Metabolite Network in Peperomia obtusifolia. Journal of Natural Products, v. 80, n. 5, p. 1275-1286, . (13/07600-3, 11/51684-1, 14/25222-9, 11/01003-8)
PAULI, IVANI; FERREIRA, LEONARDO G.; DE SOUZA, MARIANA L.; OLIVA, GLAUCIUS; FERREIRA, RAFAELA S.; DESSOY, MARCO A.; SLAFER, BRIAN W.; DIAS, LUIZ C.; ANDRICOPULO, ADRIANO D.. Molecular modeling and structure-activity relationships for a series of benzimidazole derivatives as cruzain inhibitors. Future Medicinal Chemistry, v. 9, n. 7, p. 641-657, . (11/13789-6, 13/07600-3, 13/25658-9)
CARABALLO-RODRIGUEZ, ANDRES M.; MAYOR, CASSIA A.; CHAGAS, FERNANDA O.; PUPO, MONICA T.. Amphotericin B as an inducer of griseofulvin-containing guttate in the endophytic fungus Xylaria cubensis FLe9. Chemoecology, v. 27, n. 5, p. 177-185, . (12/21803-1, 13/07600-3, 08/09540-0, 14/01651-8)
INACIO, MARIELLE CASCAES; PAZ, TIAGO ANTUNES; SOARES PEREIRA, ANA MARIA; FURLAN, MAYSA. Endophytic Bacillus megaterium and exogenous stimuli affect the quinonemethide triterpenes production in adventitious roots of Peritassa campestris (Celastraceae). PLANT CELL TISSUE AND ORGAN CULTURE, v. 131, n. 1, p. 15-26, . (14/19362-2, 13/07600-3)
FERREIRA, LEONARDO G.; OLIVA, GLAUCIUS; ANDRICOPULO, ADRIANO D.. From Medicinal Chemistry to Human Health: Current Approaches to Drug Discovery for Cancer and Neglected Tropical Diseases. Anais da Academia Brasileira de Ciências, v. 90, n. 1, 1, p. 645-661, . (13/07600-3, 13/25658-9)
VALLI, MARILIA; RUSSO, HELENA M.; BOLZANI, VANDERLAN S.. The potential contribution of the natural products from Brazilian biodiversity to bioeconomy. Anais da Academia Brasileira de Ciências, v. 90, n. 1, 1, p. 763-778, . (03/02176-7, 10/52327-5, 13/07600-3)
ALVES, THAIS B.; SOUZA-MOREIRA, TATIANA M.; VALENTINI, SANDRO R.; ZANELLI, CLESLEI E.; FURLAN, MAYSA. Friedelin in Maytenus ilicifolia Is Produced by Friedelin Synthase Isoforms. Molecules, v. 23, n. 3, . (14/03819-3, 13/07600-3, 11/10379-1)
BERNARDES, CAROLINA P.; SANTOS, NEIFE A. G.; SISTI, FLAVIA M.; FERREIRA, RAFAELA SCALCO; SANTOS-FILHO, NORIVAL A.; CINTRA, ADELIA C. O.; CILLI, EDUARDO M.; SAMPAIO, V, SUELY; SANTOS, ANTONIO C.. A synthetic snake-venom-based tripeptide (Glu-Val-Trp) protects PC12 cells from MPP+ toxicity by activating the NGF-signaling pathway. Peptides, v. 104, p. 24-34, . (11/23236-4, 13/07600-3)
SUTTON, ADAM T.; FRAIGE, KARINA; LEME, GABRIEL MAZZI; BOLZANI, VANDERLAN DA SILVA; HILDER, EMILY F.; CAVALHEIRO, ALBERTO J.; ARRUA, R. DARIO; FUNARI, CRISTIANO SOLEO. Natural deep eutectic solvents as the major mobile phase components in high-performance liquid chromatography-searching for alternatives to organic solvents. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. 410, n. 16, p. 3705-3713, . (13/15086-8, 13/07600-3, 16/50009-2)
NIVEA O. CALIXTO; MERI EMILI F. PINTO; SUELEM D. RAMALHO; MARCELA C. M. BURGER; ANTONIO F. BOBEY; MARIA CLAUDIA MARX YOUNG; VANDERLAN S. BOLZANI; ANGELO C. PINTO. The Genus Psychotria: Phytochemistry, Chemotaxonomy, Ethnopharmacology and Biological Properties. Journal of the Brazilian Chemical Society, v. 27, n. 8, p. 1355-1378, . (10/52327-5, 13/07600-3, 15/09533-7)
DE LIMA BATISTA, ANA P.; COELHO, FERNANDO; BRAGA, ATAUALPA A. C.. DFT exploration of mechanistic pathways of an aza-Morita-Baylis-Hillman reaction. THEORETICAL CHEMISTRY ACCOUNTS, v. 135, n. 8, . (13/10449-5, 15/01491-3, 13/07600-3, 13/22235-0)
LORENZON, ESTEBAN N.; SANTOS-FILHO, NORIVAL A.; RAMOS, MATHEUS A. S.; BAUAB, TAIS M.; CAMARGO, ILANA L. B. C.; CILLI, EDUARDO M.. C-terminal Lysine-Linked Magainin 2 with Increased Activity Against Multidrug-Resistant Bacteria. PROTEIN AND PEPTIDE LETTERS, v. 23, n. 8, p. 738-747, . (12/15346-7, 13/07600-3)
FERREIRA, LEONARDO G.; DOS SANTOS, RICARDO N.; OLIVA, GLAUCIUS; ANDRICOPULO, ADRIANO D.. Molecular Docking and Structure-Based Drug Design Strategies. Molecules, v. 20, n. 7, p. 13384-13421, . (13/07600-3, 13/25658-9)
FERNANDES, FABIO S.; RODRIGUES, JR., MANOEL T.; ZEOLY, LUCAS A.; CONTI, CAROLINE; ANGOLINI, CELIO F. F.; EBERLIN, MARCOS NOGUEIRA; COELHO, FERNANDO. Vinyl-1,2,4-oxadiazoles Behave as Nucleophilic Partners in Morita-Baylis-Hillman Reactions. Journal of Organic Chemistry, v. 83, n. 24, p. 15118-15127, . (18/02611-0, 13/07600-3, 16/23005-6)
FAGUNDEZ, CATHERINE; SELLANES, DIVER; PENA, STELLA; SCARONE, LAURA; AGUIAR, ANNA C. C.; DE SOUZA, JULIANA O.; GUIDO, RAFAEL V. C.; STEWART, LINDSAY; YARDLEY, VANESSA; OTTILIE, SABINE; et al. Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents. ACS Medicinal Chemistry Letters, v. 10, n. 1, p. 137-141, . (13/07600-3)
DE SOUZA, ANACLETO S.; DE OLIVEIRA, MARCELO T.; ANDRICOPULO, ADRIANO D.. Development of a pharmacophore for cruzain using oxadiazoles as virtual molecular probes: quantitative structure-activity relationship studies. Journal of Computer-Aided Molecular Design, v. 31, n. 9, p. 801-816, . (13/07600-3)
FRANCESCHINI SARRIA, ANDRE LUCIO; LOPES VILELA, ADRIANA FERREIRA; FRUGERI, BARBARA MAMMANA; FERNANDES, JOAO BATISTA; CARLOS, ROSE MARIA; DAS GRACAS FERNANDES DA SILVA, MARIA FATIMA; CASS, QUEZIA BEZERRA; CARDOSO, CARMEN LUCIA. Copper (II) and zinc (II) complexes with flavanone derivatives: Identification of potential cholinesterase inhibitors by on-flow assays. Journal of Inorganic Biochemistry, v. 164, p. 141-149, . (13/07600-3, 06/58043-3, 09/01847-1)
MAFUD, ANA C.; FERREIRA, LEONARDO G.; MASCARENHAS, YVONNE P.; ANDRICOPULO, ADRIANO D.; DE MORAES, JOSUE. Discovery of Novel Antischistosomal Agents by Molecular Modeling Approaches. Trends in Parasitology, v. 32, n. 11, p. 874-886, . (14/02282-6, 13/25658-9, 13/07600-3)
ZERAIK, MARIA LUIZA; QUEIROZ, EMERSON FERREIRA; MARCOURT, LAURENCE; CICLET, OLIVIER; CASTRO-GAMBOA, IAN; SIQUEIRA SILVA, DULCE HELENA; CUENDET, MURIEL; BOLZANI, VANDERLAN DA SILVA; WOLFENDER, JEAN-LUC. Antioxidants, quinone reductase inducers and acetylcholinesterase inhibitors from Spondias tuberosa fruits. Journal of Functional Foods, v. 21, p. 396-405, . (10/52327-5, 13/07600-3, 11/03017-6)
FERNANDES, FABIO DE SOUZA; CORMANICH, RODRIGO A.; ZEOLY, LUCAS A.; FORMIGA, ANDRE LUIZ B.; COELHO, FERNANDO. Employing Small Polyfunctionalized Molecules for a Diastereoselective Synthesis of Highly Substituted Indolines. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v. 2018, n. 24, p. 3211-3223, . (17/02364-0, 13/07600-3)
FUNARI, CRISTIANO SOLEO; CAVALHEIRO, ALBERTO JOSE; CARNEIRO, RENATO LAJARIM. Coupled monolithic columns as an alternative for the use of viscous ethanol-water mobile phases on chromatographic fingerprinting complex samples. REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY, v. 28, n. 3, p. 261-266, . (14/50926-0, 13/07600-3, 10/18840-7)
ALMEIDA, MARILIA O.; LOPES, ADRIANA A.; ROBERTO, PATRICIA G.; BERTONI, BIANCA W.; PUPO, MONICA T.. Unveiling the fungal biotransformation of hydralazine using C-13-precursor. PHYTOCHEMISTRY LETTERS, v. 26, p. 55-59, . (08/09540-0, 13/07600-3)
FERREIRA, VINICIUS G.; LEME, GABRIEL M.; CAVALHEIRO, ALBERTO J.; FUNARI, CRISTIANO S.. Online Extraction Coupled to Liquid Chromatography Analysis (OLELC): Eliminating Traditional Sample Preparation Steps in the Investigation of Solid Complex Matrices. Analytical Chemistry, v. 88, n. 17, p. 8421-8427, . (10/18840-7, 13/07600-3)
GUBIANI, JULIANA R.; NOGUEIRA, CLAUDIO R.; PEREIRA, MARCOS D. P.; YOUNG, MARIA C. M.; FERREIRA, PAULO M. P.; DE MORAES, MANOEL O.; PESSOA, CLAUDIA; BOLZANI, VANDERLAN S.; ARAUJO, ANGELA R.. Rearranged Sesquiterpenes and Branched Polyketides Produced by the Endophyte Camarops sp.. PHYTOCHEMISTRY LETTERS, v. 17, p. 251-257, . (13/07600-3)
CORNELIO, VIVIAN E.; MALUF, FERNANDO V.; FERNANDES, JOAO B.; DA SILVA, MARIA FATIMA G. F.; OLIVA, GLAUCIUS; GUIDO, RAFAEL V. C.; VIEIRA, PAULO C.. Isolation of Tiliroside from Spiranthera odoratissima as Inhibitor of Trypanosoma cruzi Glyceraldehyde-3-phosphate Dehydrogenase by Using Bioactivity-Guided Fractionation. Journal of the Brazilian Chemical Society, v. 28, n. 3, SI, p. 512-519, . (09/17538-8, 13/07600-3)
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