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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The influence of nutritional status and disease on adiponectin and TNF-alpha levels in colorectal cancer patients

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Author(s):
Vicente, Mariana Abe [1] ; Silva, Tiago Donizetti [1] ; Barao, Katia [1] ; Felipe, Aledson Vitor [1] ; Missae, Lila Oyama [2] ; Forones, Nora Manoukian [1]
Total Authors: 6
Affiliation:
[1] Escola Paulista Med, Dept Med, Div Gastroenterol, Oncol Grp, BR-04023 Sao Paulo - Brazil
[2] Dept Physiol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: NUTRICION HOSPITALARIA; v. 30, n. 1, p. 140-146, JUL 2014.
Web of Science Citations: 3
Abstract

Background: The aim of this study was to evaluate the association between adiponectin and tumor necrosis factor-a (TNF-alpha) serum levels in colorectal cancer (CRC) patients and compare these levels to clinical stage and nutritional status. Methods: A total of 79 patients were enrolled in the study (39 with CRC and 40 in the control). Nutritional status was assessed by Patient-Generated Subjective Global Assessment (PG-SGA), body mass index (BMI), and phase angle (PhA). Adiponectin and TNF-alpha serum concentrations were determined using an enzyme-linked immunosorbent assay. Results: Serum adiponectin levels were higher among CRC patients (p = 0.001). TNF-alpha serum levels were not significantly different between the groups, but patients with stage III or IV CRC had higher levels of TNF-alpha than those with lower stage disease (p = 0.037). The three tools used for the assessment of nutritional status (BMI, PhA, and PG-SGA) demonstrated that patients with a more severe nutritional deficit had higher adipocytokine levels, although these differences were significant only to TNF-alpha, when distributed PhA in tertiles. Conclusions: Adiponectin levels were higher among CRC patients. Although TNF-alpha serum levels from CRC patients did not differ significantly to the control group, CRC patients with stage III or IV had higher levels compared to those with stage I and II tumors. Nutritional status, as determined by BMI, PhA, and PG-SGA, demonstrated that patients with a greatest nutritional deficit, had higher levels of adipocytokines; however, these differences were significant only for TNF-alpha, when distributed PhA in tertiles. (AU)

FAPESP's process: 10/19191-2 - Analysis of the effectiveness of methods and indicators of nutritional status pertaining to patients with esophageal, gastric and colorectal cancer
Grantee:Nora Manoukian Forones
Support type: Regular Research Grants