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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Serum endothelin-1 measurement in healthy Maine Coon cats

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Author(s):
Itikawa, Paula Hiromi [1] ; Goldfeder, Guilherme Teixeira [1] ; Costa de Oliveira, Valeria Marinho [1] ; Matiko Akao Larsson, Maria Helena [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Med Vet & Zootecnia, BR-09500900 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: SEMINA-CIENCIAS AGRARIAS; v. 34, n. 6, 2, p. 3831-3839, 2013.
Web of Science Citations: 0
Abstract

The plasma concentration of endothelin (ET)-1 increases in human patients with congestive heart failure and is correlated with the degree of hemodynamic and functional changes. An increase in plasma ET-1 concentration is also correlated with cell proliferation, vasoconstriction, hypertrophy of cardiomyocytes and activation of cardiac fibroblasts, all of which are associated with clinical manifestations of heart failure (HF) and pathological remodeling of the heart. Hypertrophic cardiomyopathy (HCM) is the most commonly diagnosed heart disease in cats and is characterized by increased cardiac mass associated with concentric left ventricular hypertrophy (LVH), which is associated with mutations in the cardiac myosin binding protein C (MYBPC3) gene in Maine Coon (MC) cats. ET-1 serum concentrations were measured in 38 healthy MC cats using the human ELISA assay validated for the feline species. Unfortunately, the ET-1 values could not be assessed in the present study because they were above the maximum levels of sensitivity of the test used. ET-1 serum measurements without aprotinin in healthy MC cats is greater than values ET-1 plasma concentration with aprotinin reported by literature in healthy cats using the Biomedica Endothelin (1-21) diagnosis kit. Using this kit for serum ET-1 measurements without aprotinin in MC cats the dilution of samples is necessary. (AU)

FAPESP's process: 09/54251-9 - Evaluation of Maine Coon cats with hypertrophic cardiomyopathy: clinical, echocardiographic, electrocardiographic, radiographic, laboratory and by 24 hours electrocardiographic monitoring (Holter)
Grantee:Maria Helena Matiko Akao Larsson
Support type: Regular Research Grants
FAPESP's process: 10/02317-3 - DETERMINATION OF CARDIAC MARKERS IN MAINE COON CATS GENETICALLY TESTED FOR HYPERTROPHIC CARDIOMYOPATHY MUTATION
Grantee:Paula Hiromi Itikawa
Support type: Scholarships in Brazil - Master