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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hypertrophic Adenoid Is a Major Infection Site of Human Bocavirus 1

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Proenca-Modena, J. L. [1, 2, 3] ; Paula, F. E. [1, 2] ; Buzatto, G. P. [4] ; Carenzi, L. R. [4] ; Saturno, T. H. [2, 4] ; Prates, M. C. [2, 4] ; Silva, M. L. [1, 2] ; Delcaro, L. S. [5] ; Valera, F. C. P. [4] ; Tamashiro, E. [4] ; Anselmo-Lima, W. T. [4] ; Arruda, E. [1, 2]
Total Authors: 12
[1] Univ Sao Paulo, Sch Med, Dept Cell Biol, BR-14049 Ribeirao Preto - Brazil
[2] Univ Sao Paulo, Sch Med, Virol Res Ctr, BR-14049 Ribeirao Preto - Brazil
[3] Univ Estadual Campinas, UNICAMP, Dept Genet Evolut & Bioagents, Inst Biol, Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, BR-14049 Ribeirao Preto - Brazil
[5] Univ Sao Paulo, Sch Med, Dept Internal Med, BR-14049 Ribeirao Preto - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Journal of Clinical Microbiology; v. 52, n. 8, p. 3030-3037, AUG 2014.
Web of Science Citations: 4

Human bocavirus 1 (HBoV1) is associated with respiratory infections worldwide, mainly in children. Similar to other parvoviruses, it is believed that HBoV1 can persist for long periods of time in humans, probably through maintaining concatemers of the virus single-stranded DNA genome in the nuclei of infected cells. Recently, HBoV-1 was detected in high rates in adenoid and palatine tonsils samples from patients with chronic adenotonsillar diseases, but nothing is known about the virus replication levels in those tissues. A 3-year prospective hospital-based study was conducted to detect and quantify HBoV1 DNA and mRNAs in samples of the adenoids (AD), palatine tonsils (PT), nasopharyngeal secretions (NPS), and peripheral blood (PB) from patients undergoing tonsillectomy for tonsillar hypertrophy or recurrent tonsillitis. HBoV1 was detected in 25.3% of the AD samples, while the rates of detection in the PT, NPS, and PB samples were 7.2%, 10.5%, and 1.7%, respectively. The viral loads were higher in AD samples, and 27.3% of the patients with HBoV had mRNA detectable in this tissue. High viral loads and detectable mRNA in the AD were associated with HBoV1 detection in the other sample sites. The adenoids are an important site of HBoV1 replication and persistence in children with tonsillar hypertrophy. The adenoids contain high HBoV1 loads and are frequently positive for HBoV mRNA, and this is associated with the detection of HBoV1 in secretions. (AU)

FAPESP's process: 09/51818-8 - The profile of viral infections in chronic diseases of the upper respiratory tract: adenoamigdaliana hypertrophy and secretory otitis media, rhinosinusitis
Grantee:Wilma Terezinha Anselmo Lima
Support Opportunities: Research Projects - Thematic Grants