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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hologram QSAR Studies of Antiprotozoal Activities of Sesquiterpene Lactones

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Trossini, Gustavo H. G. [1] ; Maltarollo, Vinicius G. [1] ; Schmidt, Thomas J. [2]
Total Authors: 3
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, BR-05508000 Sao Paulo - Brazil
[2] Univ Munster, IPBP, D-48149 Munster - Germany
Total Affiliations: 2
Document type: Journal article
Source: Molecules; v. 19, n. 7, p. 10546-10562, JUL 2014.
Web of Science Citations: 9

Infectious diseases such as trypanosomiasis and leishmaniasis are considered neglected tropical diseases due the lack for many years of research and development into new drug treatments besides the high incidence of mortality and the lack of current safe and effective drug therapies. Natural products such as sesquiterpene lactones have shown activity against T. brucei and L. donovani, the parasites responsible for these neglected diseases. To evaluate structure activity relationships, HQSAR models were constructed to relate a series of 40 sesquiterpene lactones (STLs) with activity against T. brucei, T. cruzi, L. donovani and P. falciparum and also with their cytotoxicity. All constructed models showed good internal (leave-one-out q(2) values ranging from 0.637 to 0.775) and external validation coefficients (r(test)(2) values ranging from 0.653 to 0.944). From HQSAR contribution maps, several differences between the most and least potent compounds were found. The fragment contribution of PLS-generated models confirmed the results of previous QSAR studies that the presence of alpha, beta-unsatured carbonyl groups is fundamental to biological activity. QSAR models for the activity of these compounds against T. cruzi, L. donovani and P. falciparum are reported here for the first time. The constructed HQSAR models are suitable to predict the activity of untested STLs. (AU)

FAPESP's process: 11/11499-0 - Bioisosterism in the design of new antichagasic agents: integration of computational and experimental strategies
Grantee:Gustavo Henrique Goulart Trossini
Support Opportunities: Regular Research Grants
FAPESP's process: 13/50677-7 - Exploring epigenetic targets to fight neglected diseases: Selective sirtuin-2 inhibitors as leishmanicidal compounds
Grantee:Flavio da Silva Emery
Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE