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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cardioprotection afforded by exercise training prior to myocardial infarction is associated with autonomic function improvement

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Author(s):
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Rodrigues, Fernando [1] ; Feriani, Daniele Jardim [1] ; Barboza, Catarina Andrade [1] ; Vergilino Abssamra, Marcos Elias [1] ; Rocha, Leandro Yanase [1] ; Carrozi, Nicolle Martins [1] ; Mostarda, Cristiano [2] ; Figueroa, Diego [3] ; Honorato Souza, Gabriel Inacio [1] ; De Angelis, Katia [4] ; Irigoyen, Maria Claudia [3] ; Rodrigues, Bruno [1]
Total Authors: 12
Affiliation:
[1] Sao Judas Tadeu Univ USJT, Human Movement Lab, Sao Paulo - Brazil
[2] Fed Univ Maranhao UFMA, Sao Luis, MA - Brazil
[3] Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, Sao Paulo - Brazil
[4] Univ Nove Julho UNINOVE, Translat Physiol Lab, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: BMC CARDIOVASCULAR DISORDERS; v. 14, JUL 14 2014.
Web of Science Citations: 10
Abstract

Background: It has been suggested that exercise training (ET) protects against the pathological remodeling and ventricular dysfunction induced by myocardial infarction (MI). However, it remains unclear whether the positive adjustments on baroreflex and cardiac autonomic modulations promoted by ET may afford a cardioprotective mechanism. The aim of this study was to evaluate the effects of aerobic ET, prior to MI, on cardiac remodeling and function, as well as on baroreflex sensitivity and autonomic modulation in rats. Methods: Male Wistar rats were divided into 4 groups: sedentary rats submitted to Sham surgery (C); trained rats submitted to Sham surgery (TC); sedentary rats submitted to MI (I), trained rats submitted to MI (TI). Sham and MI were performed after ET period. After surgeries, echocardiographic, hemodynamic and autonomic (baroreflex sensitivity, cardiovascular autonomic modulation) evaluations were conducted. Results: Prior ET prevented an additional decline in exercise capacity in TI group in comparison with I. MI area was not modified by previous ET. ET was able to increase the survival and prevent additional left ventricle dysfunction in TI rats. Although changes in hemodynamic evaluations were not observed, ET prevented the decrease of baroreflex sensitivity, and autonomic dysfunction in TI animals when compared with I animals. Importantly, cardiac improvement was associated with the prevention of cardiac autonomic impairment in studied groups. Conclusions: Prior ET was effective in changing aerobic capacity, left ventricular morphology and function in rats undergoing MI. Furthermore, these cardioprotective effects were associated with attenuated cardiac autonomic dysfunction observed in trained rats. Although these cause-effect relationships can only be inferred, rather than confirmed, our study suggests that positive adaptations of autonomic function by ET can play a vital role in preventing changes associated with cardiovascular disease, particularly in relation to MI. (AU)

FAPESP's process: 13/14788-9 - Effects of exercise training and cholinergic stimulation with pyridostigmine bromide before and after myocardial infarction: role on cardiac and autonomic function, and inflammatory profile
Grantee:Bruno Rodrigues
Support Opportunities: Regular Research Grants