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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Comparative Evaluation of Antiproliferative Effects of Brazilian Green Propolis, Its Main Source Baccharis dracunculifolia, and Their Major Constituents Artepillin C and Baccharin

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de Oliveira, Pollyanna Francielli [1] ; de Souza Lima, Ildercilio Mota [1] ; Munari, Carla Carolina [1] ; Bastos, Jairo Kenupp [2] ; da Silva Filho, Ademar Alves [3] ; Tavares, Denise Crispim [1]
Total Authors: 6
[1] Univ Franca, BR-14404600 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Sao Paulo - Brazil
[3] Univ Fed Juiz de Fora, Fac Farm, Dept Ciencias Farmaceut, Juiz De Fora, MG - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Planta Medica; v. 80, n. 6, p. 490-492, APR 2014.
Web of Science Citations: 4

This study evaluated the antiproliferative activity of the Brazilian green propolis and Baccharis dracunculifolia extracts and their major compounds artepillin C and baccharin in different tumor cell lines. The lowest IC50 values observed for Brazilian green propolis and B. dracunculifolia extracts were 41.0 +/- 4.5 mu g/mL for U343 and 44.9 +/- 7.1 mu g/mL for HepG2, respectively. Regarding artepillin C and baccharin, the lowest IC50 values were 20.1 +/- 2.9 for U343 and 13.0 +/- 1.5 mu g/mL for B16F10, respectively. For the association of artepillin C plus baccharin, the lowest IC50 result was 35.2 +/- 0.5 mu g/mL for B16F10. Artepillin C and baccharin were more cytotoxic than both Brazilian green propolis and B. dracunculifolia extracts. No additive or synergistic effect was observed for the association of artepillin C plus baccharin. (AU)

FAPESP's process: 09/12019-2 - In vivo and in vitro evaluation of mutagenic/genotoxic and antimutagenic/antigenotoxic potential of baccharin, an important chemical compound of Baccharis dracunculifolia
Grantee:Pollyanna Francielli de Oliveira
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 07/07211-6 - Study of mutagenic and/or antimutagenic activity of Baccharis dracunculifolia and Artepillin C in mammalian cells
Grantee:Denise Crispim Tavares Barbosa
Support Opportunities: Regular Research Grants