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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cortex glial cells activation, associated with lowered mechanical thresholds and motor dysfunction, persists into adulthood after neonatal pain

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Sanada, Luciana Sayuri [1, 2] ; Sato, Karina Laurenti [1] ; Machado, Nathalia Leilane Berto [2] ; do Carmo, Elisabete de Cassia [2] ; Sluka, Kathleen A. [1] ; Sassoli Fazan, Valeria Paula [2]
Total Authors: 6
[1] Univ Iowa, Carver Coll Med, Dept Phys Therapy & Rehabil Sci, Iowa City, IA - USA
[2] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Neurosci & Behav Sci, Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Web of Science Citations: 5

We investigated if changes in glial activity in cortical areas that process nociceptive stimuli persisted in adult rats after neonatal injury. Neonatal pain was induced by repetitive needle prickling on the right paw, twice per day for 15 days starting at birth. Wistar rats received either neonatal pain or tactile stimulation and were tested behaviorally for mechanical withdrawal thresholds of the paws and gait alterations, after 15 (P15) or 180 (P180) days of life. Brains from rats on P15 and P180 were immunostained for glial markers (GFAP, MCP-1, OX-42) and the following cortical areas were analyzed for immunoreactivity density: prefrontal, anterior insular, anterior cingulated, somatosensory and motor cortices. Withdrawal thresholds of the stimulated paw remained decreased on P180 after neonatal pain when compared to controls. Neonatal pain animals showed increased density for both GFAP and MCP-1 staining, but not for OX-42, in all investigated cortical areas on both experimental times (P15 and P180). Painful stimuli in the neonatal period produced pain behaviors immediately after injury that persisted in adult life, and was accompanied by increase in the glial markers density in cortical areas that process and interpret pain. Thus, long-lasting changes in cortical glial activity could be, at least in part, responsible for the persistent hyperalgesia in adult rats that suffered from neonatal pain. (C) 2014 ISDN. Published by Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 12/02710-2 - Immunoreactivity in brain glial cells in young and adults rats after pain stimuli during the neonatal period
Grantee:Luciana Sayuri Sanada
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 09/07265-4 - Morphometric assessment of sural and tibial nerves myelinated and unmyelinated fibers in postnatal developing rat after nocicpetion stimuli
Grantee:Luciana Sayuri Sanada
Support Opportunities: Scholarships in Brazil - Doctorate