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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Novel Ruthenium - Gamma-linolenic Acid Complex Inhibits C6 Rat Glioma Cell Proliferation In Vitro and in the Orthotopic C6 Model In Vivo After Osmotic Pump Infusion

Miyake, Juliano Andreoli [1] ; Benadiba, Marcel [1] ; Ribeiro, Geise [2] ; Silva, Denise De Oliveira [2] ; Colquhoun, Alison [1]
Total Authors: 5
[1] Univ Sao Paulo, Dept Cell & Dev Biol, BR-05508900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Fundamental Chem, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ANTICANCER RESEARCH; v. 34, n. 4, SI, p. 1901-1911, APR 2014.
Web of Science Citations: 15

Aim: Gliomas are primary brain tumours. Gamma-linolenic acid (GLA) exerts anti-proliferative effects. Several ruthenium-containing complexes have antiproliferative effects and can be used as adjuvant therapies in cisplatin-resistant cancer. The present study reports on the anti-proliferative properties and effects on tumour morphology of a novel diruthenium-GLA complex (Ru(2)GLA) and its comparison with GLA in the C6 rat glioma model both in vitro and in vivo. Materials and Methods: In vitro and in vivo experiments were performed on C6 glioma rat cells, and in an orthotopic model. Results: Ru(2)GLA (100 mu M) appears to be an inhibitor of C6 rat glioma cell proliferation. The nuclear area of Ru(2)GLA-treated cells was 2.18-times larger than that of control cells, suggesting DNA replication occurred but mitosis was blocked in the G(2)-M phase. Ru(2)GLA (2 mM) inhibited C6 cell proliferation in vivo and the changes in tumor morphology confirm both cellular uptake and collagen fibre-binding in the extracellular matrix. Conclusion: Ru(2)GLA appears to be a low-toxicity drug and a potential candidate for anti-proliferative therapy of glioma. (AU)

FAPESP's process: 11/06592-1 - Anti-inflammatory and antitumor metallotherapeutic drugs: reactivity, properties and interactions with biocompatible hosts
Grantee:Denise de Oliveira Silva
Support type: Regular Research Grants
FAPESP's process: 05/60596-8 - Complex species with potential for application in bio-organics, catalysis, pharmacology and environmental chemistry: conception, preparation, characterization and reactivity
Grantee:Ana Maria da Costa Ferreira
Support type: Research Projects - Thematic Grants