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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neuroanatomical Classification in a Population-Based Sample of Psychotic Major Depression and Bipolar I Disorder with 1 Year of Diagnostic Stability

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Author(s):
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Serpa, Mauricio H. [1, 2, 3] ; Ou, Yangming [4] ; Schaufelberger, Maristela S. [1, 2, 3] ; Doshi, Jimit [4] ; Ferreira, Luiz K. [1, 2, 3] ; Machado-Vieira, Rodrigo [3, 5, 6] ; Menezes, Paulo R. [7] ; Scazufca, Marcia [6, 8] ; Davatzikos, Christos [4] ; Busatto, Geraldo F. [1, 2, 3] ; Zanetti, Marcus V. [1, 2, 3, 5, 6]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Fac Med, Nucl Med Ctr, Dept Psychiat, Lab Psychiat Neuroimaging LIM 21, BR-05403010 Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Nucl Med Ctr, Inst Psychiat, BR-05403010 Sao Paulo - Brazil
[3] Univ Sao Paulo, Nucl Med Ctr, Ctr Interdisciplinary Res Appl Neurosci NAPN, BR-05403010 Sao Paulo - Brazil
[4] Univ Penn, Dept Radiol, Sect Biomed Image Anal, Philadelphia, PA 19104 - USA
[5] Univ Sao Paulo, Fac Med, Dept Psychiat, Lab Neurosci LIM 27, BR-05403010 Sao Paulo - Brazil
[6] Univ Sao Paulo, Fac Med, Inst Psychiat, BR-05403010 Sao Paulo - Brazil
[7] Univ Sao Paulo, Fac Med, Dept Prevent Med, BR-01246903 Sao Paulo - Brazil
[8] Univ Sao Paulo, Fac Med, Dept Psychiat, Lab Psychopharmacol & Clin Psychophysiol LIM 23, BR-05403010 Sao Paulo - Brazil
Total Affiliations: 8
Document type: Journal article
Source: BIOMED RESEARCH INTERNATIONAL; 2014.
Web of Science Citations: 21
Abstract

The presence of psychotic features in the course of a depressive disorder is known to increase the risk for bipolarity, but the early identification of such cases remains challenging in clinical practice. In the present study, we evaluated the diagnostic performance of a neuroanatomical pattern classification method in the discrimination between psychotic major depressive disorder(MDD), bipolar I disorder (BD-I), and healthy controls (HC) using a homogenous sample of patients at an early course of their illness. Twenty-three cases of first-episode psychotic mania (BD-I) and 19 individuals with a first episode of psychotic MDD whose diagnosis remained stable during 1 year of followup underwent 1.5 T MRI at baseline. A previously validated multivariate classifier based on support vector machine (SVM) was employed and measures of diagnostic performance were obtained for the discrimination between each diagnostic group and subsamples of age-and gender-matched controls recruited in the same neighborhood of the patients. Based on T1-weighted images only, the SVM-classifier afforded poor discrimination in all 3 pairwise comparisons: BD-I versus HC; MDD versus HC; and BD-I versus MDD. Thus, at the population level and using structural MRI only, we failed to achieve good discrimination between BD-I, psychotic MDD, and HC in this proof of concept study. (AU)

FAPESP's process: 13/03905-4 - NEUROBIOLOGICAL DIFFERENCES BETWEEN TREATMENT-NAIVE PATIENTS WITH BIPOLAR DISORDER SUBTYPES I AND II
Grantee:Marcus Vinicius Zanetti
Support Opportunities: Scholarships in Brazil - Post-Doctoral