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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antioxidant and anti-diabetic potential of Passiflora alata Curtis aqueous leaves extract in type 1 diabetes mellitus (NOD-mice)

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Author(s):
Colomeu, T. C. [1] ; Figueiredo, D. [1] ; Cazarin, C. B. B. [2] ; Schumacher, N. S. G. [1] ; Marostica, Jr., M. R. [2] ; Meletti, L. M. M. [3] ; Zollner, R. L. [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, BR-13083887 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Food Engn, Dept Food & Nutr, BR-13083862 Campinas, SP - Brazil
[3] Agron Inst Campinas, BR-13012970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: International Immunopharmacology; v. 18, n. 1, p. 106-115, JAN 2014.
Web of Science Citations: 12
Abstract

Leaves of Passiflora alata Curtis were characterized for their antioxidant capacity. Antioxidant analyses of DPPH, FRAP, ABTS, ORAC and phenolic compounds were made in three different extracts: aqueous, methanol/acetone and ethanol. Aqueous extract was found to be the best solvent for recovery of phenolic compounds and antioxidant activity, when compared with methanol/acetone and ethanol. To study the anti-inflammatory properties of this extract in experimental type 1 diabetes, NOD mice were divided into two groups: the P. alata group, treated with aqueous extract of P. alata Curtis, and a non-treated control group, followed by diabetes expression analysis. The consumption of aqueous extract and water ad libitum lasted 28 weeks. The treated-group presented a decrease in diabetes incidence, a low quantity of infiltrative cells in pancreatic islets and increased glutathione in the kidney and liver (p <0.05), when compared with the diabetic and non-diabetic control-groups. In conclusion, our results suggest that the consumption of aqueous extract of P. alata may be considered a good source of natural antioxidants and compounds found in its composition can act as anti-inflammatory agents, helping in the control of diabetes. (C) 2013 Elsevier B.V. All tights reserved. (AU)

FAPESP's process: 11/06559-4 - Identification and Characterization of compounds of the aqueous extract of Passiflora alata. Effect of treatment on diabetes expression and modulation of inflammation in pancreatic islets in the NOD mouse model of type 1 diabetes (non-obese diabetic)
Grantee:Ricardo de Lima Zollner
Support Opportunities: Regular Research Grants