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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Composite interval mapping and mixed models reveal QTL associated with performance and carcass traits on chicken chromosomes 1, 3, and 4

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Rosario, M. F. [1, 2] ; Gazaffi, R. [2] ; Moura, A. S. A. M. T. [3] ; Ledur, M. C. [4] ; Coutinho, L. L. [2] ; Garcia, A. A. F. [2]
Total Authors: 6
[1] Univ Fed Sao Paulo, Sao Paulo - Brazil
[2] Univ Sao Paulo, Escola Super Agr Luiz de Queiroz, Dept Zootecnia, BR-13418900 Sao Paulo - Brazil
[3] Univ Estadual Paulista, Fac Med Vet & Zootecnia, Dept Prod Anim, BR-18618000 Botucatu, SP - Brazil
[4] Embrapa Suinos & Aves, BR-89700000 Concordia, SC - Brazil
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF APPLIED GENETICS; v. 55, n. 1, p. 97-103, FEB 2014.
Web of Science Citations: 0

Interval mapping (IM) implemented in QTL Express or GridQTL is widely used, but presents some limitations, such as restriction to a fixed model, risk of mapping two QTL when there may be only one and no discrimination of two or more QTL using both cofactors located on the same and other chromosomes. These limitations were overcome with composite interval mapping (CIM). We reported QTL associated with performance and carcass traits on chicken chromosomes 1, 3, and 4 through implementation of CIM and analysis of phenotypic data using mixed models. Thirty-four microsatellite markers were used to genotype 360 F-2 chickens from crosses between males from a layer line and females from a broiler line. Sixteen QTL were mapped using CIM and 14 QTL with IM. Furthermore, of those 30 QTL, six were mapped only when CIM was used: for body weight at 35 days (first and third peaks on GGA4), body weight at 41 days (GGA1B and second peak on GGA4), and weights of back and legs (both on GGA4). Three new regions had evidence for QTL presence: one on GGA1B associated with feed intake 35-41 d at 404 cM (LEI0107-ADL0183) and two on GGA4 associated with weight of back at 163 cM (LEI0076-MCW0240) and weight gain 35-41 d, feed efficiency 35-41 d and weight of legs at 241 cM (LEI0085-MCW0174). We dissected one more linked QTL on GGA4, where three QTL for BW35 and two QTL for BW41 were mapped. Therefore, these new regions mapped here need further investigations using high-density SNP to confirm these QTL and identify candidate genes associated with those traits. (AU)

FAPESP's process: 12/13272-6 - Development of statistical models for genome wide association studies to identify genotype-environment interaction for water stress in sorghum
Grantee:Rodrigo Gazaffi
Support Opportunities: Scholarships in Brazil - Post-Doctoral