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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

TLR2, TLR4 and CD14 Recognize Venom-Associated Molecular Patterns from Tityus serrulatus to Induce Macrophage-Derived Inflammatory Mediators

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Zoccal, Karina Furlani [1] ; Bitencourt, Claudia da Silva [1] ; Garcia Paula-Silva, Francisco Wanderley [1] ; Sorgi, Carlos Arterio [1] ; Figueiredo Bordon, Karla de Castro [2] ; Arantes, Eliane Candiani [2] ; Faccioli, Lucia Helena [1]
Total Authors: 7
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14049 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Quim & Fis, BR-14049 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: PLoS One; v. 9, n. 2 FEB 7 2014.
Web of Science Citations: 31

Scorpion sting-induced human envenomation provokes an intense inflammatory reaction. However, the mechanisms behind the recognition of scorpion venom and the induction of mediator release in mammalian cells are unknown. We demonstrated that TLR2, TLR4 and CD14 receptors sense Tityus serrulatus venom (TsV) and its major component, toxin 1 (Ts1), to mediate cytokine and lipid mediator production. Additionally, we demonstrated that TsV induces TLR2- and TLR4/MyD88-dependent NF-kappa B activation and TLR4-dependent and TLR2/MyD88-independent c-Jun activation. Similar to TsV, Ts1 induces MyD88-dependent NF-kappa B phosphorylation via TLR2 and TLR4 receptors, while c-Jun activation is dependent on neither TLR2 nor TLR4/MyD88. Therefore, we propose the term venom-associated molecular pattern (VAMP) to refer to molecules that are introduced into the host by stings and are recognized by PRRs, resulting in inflammation. (AU)

FAPESP's process: 10/18179-9 - Tityus serrulatus scorpion venom is recognized by pattern recognition receptors and induces cell activation and inflammation
Grantee:Karina Furlani Zoccal
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 09/07169-5 - Lipid mediators as regulators of immune response
Grantee:Lúcia Helena Faccioli
Support Opportunities: Research Projects - Thematic Grants