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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Breakthrough Candidemia Due to Multidrug-Resistant Candida glabrata during Prophylaxis with a Low Dose of Micafungin

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Author(s):
Bizerra, Fernando Cesar [1] ; Jimenez-Ortigosa, Cristina [2] ; Souza, Ana Carolina R. [1] ; Breda, Giovanni Luis [3] ; Queiroz-Telles, Flavio [3] ; Perlin, David S. [2] ; Colombo, Arnaldo L. [1]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Paulo, Lab Especial Micol, Disciplina Infectol, Sao Paulo - Brazil
[2] Rutgers State Univ, New Jersey Med Sch, Publ Hlth Res Inst, Newark, NJ 07102 - USA
[3] Univ Fed Parana, Hosp Clin, BR-80060000 Curitiba, Parana - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Antimicrobial Agents and Chemotherapy; v. 58, n. 4, p. 2438-2440, APR 2014.
Web of Science Citations: 35
Abstract

We identified a case of breakthrough candidemia in a 25-year-old patient receiving micafungin prophylaxis (50 mg/day). Five Candida glabrata isolates were obtained from blood cultures and were classified as multidrug-resistant isolates, since all of them exhibited high MICs for echinocandin and azole drugs. A mutation (S663F) in hot spot 1 of the FKS2 gene was found in all five isolates. This mutation yielded a 1,3-beta-D-glucan synthase enzyme with highly reduced sensitivities to echinocandin drugs. (AU)

FAPESP's process: 07/08575-1 - Hematogenic candidiasis: a multidisciplinary approach for the improvement of diagnostic tools and caracterization of biomarkers related to its prognosis
Grantee:Arnaldo Lopes Colombo
Support type: Research Projects - Thematic Grants
FAPESP's process: 10/17179-5 - Proteomics as a strategy to identify biomarkers for early diagnosis of candidemia
Grantee:Fernando César Bizerra
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/04769-4 - Candida parapsilosis complex: epidemiological peculiarities, virulence and mechanisms of antifungal resistance
Grantee:Ana Carolina Remondi Souza
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/04767-1 - Candida parapsilosis complex: epidemiological peculiarities, virulence and mechanisms of antifungal resistance
Grantee:Arnaldo Lopes Colombo
Support type: Regular Research Grants