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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antibacterial evaluation of Styrax pohlii and isolated compounds

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Author(s):
Camila Spereta Bertanha [1] ; Susane Hellen Utrera [1] ; Valéria Maria Melleiro Gimenez [3] ; Milton Groppo [3] ; Márcio Luis Andrade e Silva [5] ; Wilson Roberto Cunha [1] ; Carlos Henrique Gomes Martins [1] ; Ana Helena Januário [8] ; Patrícia Mendonça Pauletti [9]
Total Authors: 9
Affiliation:
[1] Univ Franca, Ctr Res Exact & Technol Sci, BR-14404600 Franca, SP - Brazil
[2] Centro Universitário Claretiano - Brasil
[3] Univ Fed Sao Paulo, Fac Philosophy Sci & Literature, Sao Paulo - Brazil
[4] Universidade de Franca. Center for Research in Exact and Technological Sciences - Brasil
[5] Universidade de Franca. Center for Research in Exact and Technological Sciences - Brasil
[6] Universidade de Franca. Center for Research in Exact and Technological Sciences - Brasil
Total Affiliations: 6
Document type: Journal article
Source: Brazilian Journal of Pharmaceutical Sciences; v. 49, n. 4, p. 653-658, 2013-12-00.
Abstract

The antibacterial activity of the compounds egonol (1) and homoegonol (2), of the crude ethanolic extract of Styrax pohlii (Styracaceae) aerial parts (EE), and of its n-hexane (HF), EtOAc (EF), n-BuOH (BF), and hydromethanolic (HMF) fractions was evaluated against the following microorganisms: Streptococcus pneumoniae (ATCC 6305), S. pyogenes (ATCC 19615), Haemophilus influenzae (ATCC 10211), Pseudomonas aeruginosa (ATCC 27853), and Klebsiella pneumoniae (ATCC 10031). The broth microdilution method was used for determination of the minimum inhibitory concentration (MIC) during preliminary evaluation of antibacterial activity. The EE yielded MIC values of 400 µg/mL for S. pneumoniae and P. aeruginosa and 300 µg/mL for H. influenzae. The HF and EF fractions exhibited enhanced antibacterial activity, with MIC values of 200 µg/mL against S. pneumoniae, but only EF displayed activity against H. influenzae (MIC 200 µg/mL). The best MIC value with compounds 1 and 2 (400 µg/mL) was obtained for (1) against S. pneumoniae and P. aeruginosa. Therefore, 1 exhibited weak antibacterial activity against these standard strains. (AU)

FAPESP's process: 08/01268-9 - Phytochemical study and evaluation of the antimalarial, antimicrobial and acetylcholinesterase inhibition activities from the São Paulo State cerrado native species
Grantee:Ana Helena Januário
Support type: Regular Research Grants
FAPESP's process: 09/02535-3 - Phtyochemistry study of Styrax pohlii A.DC. (Styracaceae)
Grantee:Camila Spereta Bertanha
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 08/10283-1 - Phytochemistry study and evaluation of mutagenicity, antimutagenicity and cyclooxygenase inhibitory activity from Styrax (Styracaceae)
Grantee:Patricia Mendonça Pauletti
Support type: Regular Research Grants
FAPESP's process: 13/09280-6 - Phytochemistry study and evaluation of the cytotoxicity and lipoxygenase inhibitory activity from Cerrado plants
Grantee:Patricia Mendonça Pauletti
Support type: Regular Research Grants