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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Kinetic and mechanistic studies on reactions of diruthenium(II,III) with biologically relevant reducing agents

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Silva Ribeiro Santos, Rodrigo Luis [1, 2] ; van Eldik, Rudi [2] ; Silva, Denise de Oliveira [1]
Total Authors: 3
[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo - Brazil
[2] Univ Erlangen Nurnberg, Dept Chem & Pharm, D-91058 Erlangen - Germany
Total Affiliations: 2
Document type: Journal article
Source: DALTON TRANSACTIONS; v. 42, n. 48, p. 16796-16805, 2013.
Web of Science Citations: 11

Diruthenium(II,III)-tetracarboxylates have shown promising anticancer properties as metallotherapeutics. On the basis of the role that bio-reducing agents may play on the mode of action of ruthenium-based anticancer drugs, we performed detailed kinetic studies on the reaction of ascorbic acid and glutathione with the {[}Ru-2(RCOO)(4)](+) paddlewheel framework by using the non-drug, diaqua complex ion {[}Ru-2(CH3COO)(4)(H2O)(2)](+). In the presence of the reducing agents, the diaqua-Ru-2 species first undergo a ligand substitution reaction by which the axially-coordinated water is displaced by the reducing agent. In both cases, this reaction is followed by an intra-molecular electron transfer process during which the metal-metal center is reduced from Ru-2(5+) to Ru-2(4+) and the reducing agent is oxidized. Product analyses were performed with the application of ESI-MS and H-1-NMR techniques. Rate and activation parameters are reported for the different reaction steps. (AU)

FAPESP's process: 05/60596-8 - Complex species with potential for application in bio-organics, catalysis, pharmacology and environmental chemistry: conception, preparation, characterization and reactivity
Grantee:Ana Maria da Costa Ferreira
Support type: Research Projects - Thematic Grants
FAPESP's process: 11/06592-1 - Anti-inflammatory and antitumor metallotherapeutic drugs: reactivity, properties and interactions with biocompatible hosts
Grantee:Denise de Oliveira Silva
Support type: Regular Research Grants