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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

New Isoniazid Complexes, Promising Agents Against Mycobacterium tuberculosis

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Author(s):
Poggi, Mariana [1] ; Barroso, Rafael [2] ; Costa-Filho, Antonio Jose [2] ; de Barros, Heloisa Barbosa [3] ; Pavan, Fernando [3] ; Leite, Clarice Queico [3] ; Gambino, Dinorah [1] ; Helvecia Torre, Maria [1]
Total Authors: 8
Affiliation:
[1] Univ Republica, Fac Quim, Catedra Quim Inorgan, Montevideo 11800 - Uruguay
[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP - Brazil
[3] Univ Estadual Paulista, UNESP, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of the Mexican Chemical Society; v. 57, n. 3, p. 198-204, JUL-SEP 2013.
Web of Science Citations: 13
Abstract

Tuberculosis (TB) is a public health disease that produces several million deaths annually worldwide. Due to this critical situation and the appearance of drug-resistant microbial strains, innovation in TB drug discovery is a research priority. In this work, the synthesis and characterization by elemental analysis, thermogravimetry, conductimetric measurements and spectroscopies UV-Vis, IR and EPR of [Cu(INH)(H2O)]SO4 ⋅2H2O (Cu-INH) and [CoCl(INH)2(H2O)] Cl⋅2.5H2O (Co-INH) complexes with isoniazid (INH) are reported. Besides, the lipophilicity, the activity against Mycobacterium tuberculosis (MIC Cu-INH = 0.78 µg/mL and MIC Co-INH = 0.19 µg/mL) and the cytotoxicity (IC50 = 48.8 and 625 µg/mL for the copper and cobalt complexes, respectively) were measured and the selectivity index (62.5 for Cu-INH and 3205 for Co-INH) was calculated. These results indicate that these complexes are good candidates for further studies. (AU)

FAPESP's process: 11/11593-7 - Research for new drugs against tuberculosis: laboratory improvement to perform pre-clinical trials
Grantee:Fernando Rogério Pavan
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 09/06499-1 - Determination of in vitro and in vivo anti-tuberculosis activity of phosphines/diimines Ru (II) complexes
Grantee:Clarice Queico Fujimura Leite
Support Opportunities: Regular Research Grants