Podoplanin and VEGF-C Immunoexpression in Oral Squ... - BV FAPESP
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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Podoplanin and VEGF-C Immunoexpression in Oral Squamous Cell Carcinomas: Prognostic Significance

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Author(s):
Almeida, Aroldo Dos Santos [1] ; Oliveira, Denise Tostes [1] ; Pereira, Michele Conceicao [2] ; Sita Faustino, Simone Eloiza [1] ; Nonogaki, Suely [3] ; Carvalho, Andre Lopes [4] ; Kowalski, Luiz Paulo [5]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, Sect Pathol, Sao Paulo - Brazil
[2] Univ Fed Sao Joao del Rei, Divinopolis, MG - Brazil
[3] Adolfo Lutz Inst, Sao Paulo - Brazil
[4] Barretos Canc Hosp, Dept Head & Neck Surg, Barretos, SP - Brazil
[5] Canc Hosp AC Camargo, Dept Head & Neck Surg & Otorhinolaryngol, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: ANTICANCER RESEARCH; v. 33, n. 9, p. 3969-3976, SEP 2013.
Web of Science Citations: 10
Abstract

Background: This study evaluated the clinical significance of podoplanin and vascular endothelial growth factor-C (VEGF-C) expression in oral squamous cell carcinoma (OSCC). Patients and Methods: The immunohistochemical expression of podoplanin and VEGF-C were investigated in 42 well-differentiated OSCCs. The Chi-square test was used to analyze the association of biomarker expression with the clinical characteristics, treatment, and outcome, as well as with histopathological microscopic features and histopathological malignancy index. The relationship between podoplanin, VEGF-C and prognosis was also studied. Survival rates were calculated by the Kaplan Meier method. Results: Strong podoplanin expression was associated with male gender (p=0.037) and with early clinical stage (I-II) (p=0.027). Strong podoplanin expression was more frequently found in patients with perineural infiltration. Podoplanin and VEGF-C expression were not significant prognostic factors for patients with OSCC. Conclusion: These results suggest that the strong podoplanin and VEGF-C expression by malignant cells is associated with perineural invasion in patients with OSCC. (AU)

FAPESP's process: 05/04577-4 - Influence of VEGF-C and lymphatic vessel density on regional metastasis and prognosis of patients with oral squamous cell carcinoma
Grantee:Denise Tostes Oliveira
Support Opportunities: Regular Research Grants
FAPESP's process: 07/04907-0 - VEGF-C and lymphatic vessel density in oral squamous cell carcinoma: association with occult lymph node metastases and patients' prognosis
Grantee:Simone Eloiza Sita Faustino
Support Opportunities: Scholarships in Brazil - Doctorate