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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Visceral fat and coronary artery calcification in patients with chronic kidney disease

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Cordeiro, Antonio Carlos [1, 2, 3] ; Qureshi, Abdul Rashid [2, 3] ; Lindholm, Bengt [2, 3] ; Amparo, Fernanda Cassullo [4] ; Tito-Paladino-Filho, Antonio [5] ; Perini, Marcela [5] ; Lourenco, Fernanda Silvestre [5] ; Francisco Pinto, Ibraim Masciarelli [5] ; Amodeo, Celso [1] ; Carrero, Juan Jesus [2, 3]
Total Authors: 10
[1] Dante Pazzanese Inst Cardiol, Dept Hypertens & Nephrol, Sao Paulo - Brazil
[2] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm - Sweden
[3] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm - Sweden
[4] Dante Pazzanese Inst Cardiol, Dept Nutr, Sao Paulo - Brazil
[5] Dante Pazzanese Inst Cardiol, Dept Radiol, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Nephrology Dialysis Transplantation; v. 28, n. 4, p. 152-159, NOV 2013.
Web of Science Citations: 21

Background. Abdominal fat is a metabolically active tissue which has been associated with cardiovascular events and death in chronic kidney disease (CKD) patients. We explore here the association between surrogates of abdominal fat and coronary artery calcium score (CACs). Methods. Cross-sectional analysis of 232 non-dialysis-dependent CKD patients Stages 3-5 (median age 60 {[}25th-75th percentile 52-67] years; 60% men). Visceral adipose tissue (VAT) and CACs were assessed by computed tomography. Surrogates of abdominal fat included VAT and waist circumference (WC). Results. VAT was positively associated with CACs in univariate analysis (rho = 0.23). Across increasing VAT quartiles, patients were older, more often men and smokers. Although increasing VAT quartiles associated with higher glomerular filtration rate and leptin, better nutritional status (subjective global assessment) as well as larger muscle stores and strength, they were also more insulin resistant (HOMA-IR), dyslipidemic and inflamed (C-reactive protein and white blood cells). In addition, CACs were incrementally higher. Clinically evident coronary artery calcification (CACs >= 10 Agatston) was present in 63% of the patients. Both increased visceral fat (odd ratio 1.60 {[}95% CI 1.23-2.09] per standard deviation increase) and increased WC (1.05 {[}1.01-1.12] per cm increase), augmented the odds to present calcification. Such associations remained statistically significant after extensive multivariate adjustment for confounders. Conclusions. Abdominal fat is associated with coronary artery calcification in non-dialysis dependent CKD patients, supporting its potential role as a cardiovascular risk factor in uremia. (AU)

FAPESP's process: 10/16593-2 - Association between traditional, novel and uremic related risk factors and morbidity/mortality (all-cause and cardiovascular) in chronic kidney disease patients
Grantee:Antonio Carlos Cordeiro Silva Júnior
Support type: Regular Research Grants