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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aqueous Morita-Baylis-Hillman Reaction of Unprotected Isatins with Cyclic Enones

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Author(s):
Gomes, Juliana C. [1, 2] ; Sirvent, Jordi [1] ; Moyano, Albert [1] ; Rodrigues, Jr., Manoel T. [2] ; Coelho, Fernando [2]
Total Authors: 5
Affiliation:
[1] Univ Barcelona, Fac Quim, Dept Quim Organ, E-08028 Barcelona, Catalonia - Spain
[2] Univ Estadual Campinas, Inst Chem, Lab Synth Nat Prod & Drugs, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: ORGANIC LETTERS; v. 15, n. 22, p. 5838-5841, NOV 15 2013.
Web of Science Citations: 12
Abstract

The readily available bicyclic imidazolyl alcohol 1 is a unique catalyst for the aqueous Morita-Baylis-Hillman (MBH) reaction between unprotected isatins and cyclic enones that gives access to a variety of potentially very useful 3-substituted 3-hydroxy-2-oxindoles in an operationally simple, efficient, and environmentally friendly way. The hydroxyl group of the catalyst is believed to stabilize the betaine intermediate formed in the first step of the MBH reaction. (AU)

FAPESP's process: 11/20033-5 - Synthesis of heterocycles using Morita-Baylis-Hillman adducts
Grantee:Fernando Antonio Santos Coelho
Support Opportunities: Regular Research Grants