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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Interleukin 4 haplotypes of susceptibility to chronic periodontitis are associated with IL-4 protein levels but not with clinical outcomes of periodontal therapy

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Anovazzi, Giovana [1, 2] ; Finoti, Livia S. [1, 2] ; Corbi, Samia C. T. [1, 2] ; Kim, Yeon J. [2] ; Marcaccini, Andrea M. [3] ; Gerlach, Raquel F. [3] ; Capela, Marisa V. [4] ; Orrico, Silvana R. P. [2] ; Cirelli, Joni A. [2] ; Scarel-Caminaga, Raquel M. [1]
Total Authors: 10
[1] UNESP Sao Paulo State Univ, Sch Dent Araraquara, Dept Morphol, BR-14801903 Sao Paulo - Brazil
[2] UNESP Sao Paulo State Univ, Sch Dent Araraquara, Dept Oral Diag & Surg, BR-14801903 Sao Paulo - Brazil
[3] Univ Sao Paulo, Dent Sch Ribeirao Preto, Dept Morphol Stomatol & Physiol, BR-09500900 Sao Paulo - Brazil
[4] UNESP Sao Paulo State Univ, Inst Chem Araraquara, Dept Phys Chem, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: HUMAN IMMUNOLOGY; v. 74, n. 12, p. 1688-1695, DEC 2013.
Web of Science Citations: 8

Different IL4 haplotypes were associated to susceptibility to/or protection against chronic periodontitis (CP). The aim of this study was to investigate if individuals carrying different haplotypes would present differences in clinical periodontal parameters and in the IL-4 levels at baseline, 45 and 90 days after nonsurgical periodontal therapy. 62 patients were subdivided: genetically protected without CP (PH), genetically protected with CF (PCP), genetically susceptible with CP (SCP), genetically susceptible without CF (healthy) (SH). Clinical examination and gingival crevicular fluid (GCF) collection were performed for all patients, and IL-4 levels were measured by ELISA. At baseline, higher values for plaque index (PI, p = 0.013), gingival index (GI, p = 0.005) were observed for the SCP group in comparison to the PCP group but not after the completion of periodontal therapy. 45 and 90 days after the non-surgical therapy, PCP demonstrated significantly higher IL-4 levels than the SCP (p = 0.000002). Correlation analysis showed different results between clinical parameters and IL-4 production or GCF volume for groups with different genetic loads. The IL4 gene which was previously associated with susceptibility to CP was related with differences in the IL-4 protein levels in the GCF. However, independent of genetic carriage, individuals responded similarly to this therapy. (C) 2013 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 09/08773-3 - Clinical, microbiological and imunological analyses in individuals with genetic susceptibility to periodontal disease
Grantee:Raquel Mantuaneli Scarel Caminaga
Support Opportunities: Regular Research Grants
FAPESP's process: 09/11321-7 - Investigating multifactorial periodontal disease: comparison of clinical and immunological data between genetically susceptible and not susceptible individuals to Periodontitis
Grantee:Giovana Anovazzi Medeiros
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 03/10424-0 - Investigation of polymorphisms in the promoter region of interleukin 8 in Brazilian individuals with chronic periodontitits
Grantee:Raquel Mantuaneli Scarel Caminaga
Support Opportunities: Regular Research Grants