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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chemical composition and invitro schistosomicidal activity of the essential oil from the flowers of Bidens sulphurea (Asteraceae)

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Author(s):
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Aguiar, G. P. [1] ; Melo, N. I. [1] ; Wakabayashi, K. A. L. [1] ; Lopes, M. H. S. [1] ; Mantovani, A. L. L. [1] ; Dias, H. J. [1] ; Fukui, M. J. [1] ; Keles, L. C. [1] ; Rodrigues, V. [2] ; Groppo, M. [3] ; Silva-Filho, A. A. [1, 4] ; Cunha, W. R. [1] ; Magalhaes, L. G. [1] ; Crotti, A. E. M. [1]
Total Authors: 14
Affiliation:
[1] Univ Franca, Nucleo Pesquisas Ciencias Exatas & Tecnol, Franca, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Ribeirao Preto, SP - Brazil
[4] Univ Fed Juiz de Fora, Fac Farm, Juiz De Fora, MG - Brazil
Total Affiliations: 4
Document type: Journal article
Source: NATURAL PRODUCT RESEARCH; v. 27, n. 10, p. 920-924, MAY 1 2013.
Web of Science Citations: 13
Abstract

In this study, the chemical composition and the invitro schistosomicidal properties of the essential oil obtained from Bidens sulphurea flowers (Bs-EO) were investigated. Its major constituents were identified as being 2,6-di-tert-butyl-4-methylphenol (44.98%), germacrene D (33.70%) and -caryophyllene (10.23%). Bs-EO at 100 mu gmL(-1) caused death of all the adult worms and promoted separation of the couple pairs into individual male and female within 48h, besides leading to a significant decrease in the motility of the parasites. This oil was also responsible for a remarkable reduction in the number of eggs and the percentage of developed eggs produced by adult worms. These results suggest that the Bs-EO can be considered a promising source for the development of new schistosomicidal agents. (AU)

FAPESP's process: 10/17443-4 - Evaluation of the antimicrobial and schistossomicidal potential of Bidens sulphurea (Cav.) Sch. Bip. (Asteraceae)
Grantee:Gabriela de Paula Aguiar
Support type: Scholarships in Brazil - Scientific Initiation