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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Rhenium mixed-ligand complexes with S,N, S-tridentate thiosemicarbazone/thiosemicarbazide ligands

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Maia, Pedro I. da S. [1] ; Nguyen, Hung Huy [2] ; Hagenbach, Adelheid [3] ; Bergemann, Silke [4] ; Gust, Ronald [5] ; Deflon, Victor M. [1] ; Abram, Ulrich [3]
Total Authors: 7
[1] Univ Sao Paulo, Inst Quim Sao Carlos, Sao Carlos, SP - Brazil
[2] Hung Huy Nguyen, Hanoi Univ Sci, Dept Chem, Hanoi - Vietnam
[3] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin - Germany
[4] Free Univ Berlin, Inst Pharm, D-14195 Berlin - Germany
[5] Univ Innsbruck, Inst Pharm, A-6020 Innsbruck - Austria
Total Affiliations: 5
Document type: Journal article
Source: DALTON TRANSACTIONS; v. 42, n. 14, p. 5111-5121, 2013.
Web of Science Citations: 15

Rhenium(V) complexes containing tridentate thiosemicarbazones/thiosemicarbazides (H(2)L1) derived from N-{[}N', N'-dialkylamino(thiocarbonyl)] benzimidoyl chlorides with 4,4-dialkylthiosemicarbazides have been synthesized by ligand-exchange reactions starting from {[}ReOCl(L1)]. The chlorido ligand of {[}ReOCl-(L1)] (4) is readily replaced and reactions with ammonium thiocyanate or potassium cyanide give {[}ReO-(NCS)(L1)] (6) and {[}ReO(CN)(L1)] (7), respectively. The reaction of (NBu4){[}ReOCl4] with H(2)L1 and two equivalents of ammonium thiocyanate, however, gives in a one-pot reaction {[}ReO(NCS)(2)(HL1)] (8), in which the pro-ligand H(2)L1 is only singly deprotonated. An oxo-bridged, dimeric nitridorhenium(V) compound of the composition {[}[ReN(HL1)](2)O] (11) is obtained from a reaction of (NBu4){[}ReOCl4], H(2)L1 and sodium azide. The six-coordinate complexes {[}ReO(L1)(Ph(2)btu)] (12), where HPh2btu is N, N-diphenyl-N'-benzoylthiourea, can be obtained by treatment of {[}ReOCl(L1)] with HPh(2)btu in the presence of NEt3. Studies of the antiproliferative effects of the {[}ReOX(L1)] system (X = Cl-, NCS- or CN-) on breast cancer cells show that the lability of a monodentate ligand seems to play a key role in the cytotoxic activity of the metal complexes, while the substitution of this ligand by the chelating ligand Ph(2)btu(-) completely terminates the cytotoxicity. (AU)

FAPESP's process: 11/16380-1 - Au, Re and Tc thiosemicarbazones complexes of interest in the development pharmaceuticals or radiopharmaceuticals for diagnostic or therapy
Grantee:Pedro Ivo da Silva Maia
Support Opportunities: Scholarships in Brazil - Post-Doctoral