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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Differences and Similarities among Parotoid Macrogland Secretions in South American Toads: A Preliminary Biochemical Delineation

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Sciani, Juliana Mozer [1] ; Angeli, Claudia Blanes [2] ; Antoniazzi, Marta M. [3] ; Jared, Carlos [3] ; Pimenta, Daniel Carvalho [1]
Total Authors: 5
[1] Inst Butantan, Lab Bioquim & Biofis, BR-05503900 Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Ciencias Biomed, Dept Parasitol, BR-05508000 Sao Paulo - Brazil
[3] Inst Butantan, Lab Biol Celular, BR-05503900 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 26

Amphibians are known by cutaneous glands, spread over the skin, containing toxins (proteins, peptides, biogenic amines, steroidal bufadienolides, and alkaloids) used as chemical defense against predators and microbial infection. Toads are characterized by the presence of parotoid macroglands. The common toads have lately been divided into two genera: Bufo (Europe, Asia, and Africa) and Rhinella (South America). Basal Rhaebo genus is exclusively of Central America and Amazon region. Although Rhinella and Rhaebo are related, species may share differences due to the diversity of environments that they live in. In this work, we have performed a biochemical characterization of the components of the poison of eight Rhinella species and one Rhaebo by means of RP-HPLC with either UV or MS detection and by SDS-PAGE, in order to verify whether phylogenetic and biological differences, such as habitat, diet, and defensive strategies, between them may also be reflected in poison composition. Although some components were common among the secretions, we were able to identify exclusive molecules to some species. The fact that closely related animals living in different habitats secrete different molecules into the skin is an indication that biological features, and not only evolution, seem to directly influence the skin secretion composition. (AU)

FAPESP's process: 07/08478-6 - Biological-driven biochemical characterization of peptides and proteins isolated from Echinometra lucunter.
Grantee:Juliana Mozer Sciani
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 07/02476-1 - Identification and biochemical characterization of peptides and proteins present in the skin secretion of Chaunus jimi (Bufonidae, anura, amphibia)
Grantee:Daniel Carvalho Pimenta
Support Opportunities: Regular Research Grants