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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Adipocytokines in primary antiphospholipid syndrome: potential markers of low-grade inflammation, insulin resistance and metabolic syndrome

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Rodrigues, C. E. M. [1] ; Vendramini, M. B. [1] ; Bueno, C. [1] ; Bonfa, E. [1] ; de Carvalho, J. F. [1]
Total Authors: 5
[1] Univ Sao Paulo, Fac Med, Div Rheumatol, Hosp Clin, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY; v. 30, n. 6, p. 871-878, NOV-DEC 2012.
Web of Science Citations: 9

Objective This study was undertaken to evaluate a possible association of adipocytokines with metabolic syndrome (MetS), inflammation and other cardiovascular risk factors in primary antiphospholipid syndrome (PAPS). Methods Fifty-six PAPS patients and 72 controls were included. Adiponectin, leptin, visfatin, resistin, plasminogen activator inhibitor-1 (PAI-1), lipoprotein (a), glucose, ESR, CRP, uric acid and lipid profiles were measured. The presence of MetS was determined as defined by the International Diabetes Federation (IDF), and insulin resistance was rated using the homeostasis model assessment (HOMA) index. Results Concentrations of leptin were higher {[}21.5 (12.9-45.7) ng/mL] in PAPS patients than in the controls ({[}2.1 (6.9-26.8) ng/mL), p=0.001]. In PAPS patients, leptin and PAI-1 levels were positively correlated with BMI (r=0.61 and 0.29), HOMA-IR (r=0.71 and 0.28) and CRP (r=0.32 and 0.36). Adiponectin levels were negatively correlated with BMI (r=-0.28), triglycerides (r=-0.43) and HOMA-IR (r=-0.36) and positively correlated with HDL-c (r=0.37) and anti-beta 2GPI IgG (r=0.31). The presence of MetS in PAPS patients was associated with higher levels of leptin (p=0.002) and PAI-1 (p=0.03) levels and lower levels of adiponectin (p=0.042). Variables that independently influenced the adiponectin concentration were the triglyceride levels (p<0.001), VLDL-c (P=0.002) and anti-beta 2GPI IgG (p=0.042); the leptin levels were BMI (p<0.001), glucose (p=0.046), HOMA-IR (p<0.001) and ESR (p=0.006); and the PAI-1 levels were CRP (p=0.013) and MetS (p=0.048). Conclusion This study provides evidence that adipocytokines may be involved in low-grade inflammation, insulin resistance and MetS in PAPS patients. (AU)

FAPESP's process: 09/14784-8 - Evaluation of metabolic syndrome in patients with primary antiphospholipid syndrome
Grantee:Jozélio Freire de Carvalho
Support Opportunities: Regular Research Grants