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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genetic features and molecular epidemiology of Enterococcus faecium isolated in two university hospitals in Brazil

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Author(s):
Pinheiro da Silva, Leila Priscilla [1] ; Pitondo-Silva, Andre [1] ; Martinez, Roberto [2] ; da Costa Darini, Ana Lucia [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE; v. 74, n. 3, p. 267-271, NOV 2012.
Web of Science Citations: 13
Abstract

The global emergence of vancomycin-resistant Enterococcus faecium (VREfm) has been characterized by a clonal spread of strains belonging to clonal complex 17 (CC17). Genetic features and clonal relationships of 53 VREfm isolated from patients in 2 hospitals in Ribeirao Preto, Sao Paulo, Brazil, during 2005-2010 were determined as a contribution to the Brazilian evolutionary history of these nosocomial pathogens. All isolates were daptomycin susceptible, vancomycin-resistant, and had the vanA gene. The predominant virulence genes were acm and esp. Only 5 VREfm isolated in 2005-2006 had intact Tn1546, while 81% showed Tn1546 with deleted left extremity and insertion of IS1251 between the vanS and vanH genes. Multilocus sequence typing analysis permitted the identification of 9 different sequence types (STs), with 5 being new ones (656, 657, 658, 659, and 660). Predominant STs were ST412 and ST478, all belonging to CC17, except ST658. This is the first report of the ST78 in Brazil. (c) 2012 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 10/01463-6 - Molecular epidemiology and genetics of vancomycin resistance in enterococci isolated from patients in two hospitals in Ribeirao Preto
Grantee:Leila Priscilla Pinheiro da Silva
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 11/18574-8 - Molecular epidemiology of VRE isolates from pacientes from two hospitals and investigation of daptomycin susceptibility
Grantee:Ana Lúcia da Costa Darini
Support Opportunities: Regular Research Grants