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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys

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Author(s):
Motta, Lucimar B. [1] ; Furlan, Claudia M. [1] ; Santos, Deborah Y. A. C. [1] ; Salatino, Maria L. F. [1] ; Duarte-Almeida, Joaquim M. [2] ; Negri, Giuseppina [2] ; de Carvalho, Joao E. [3] ; Ruiz, Ana Lucia T. G. [3] ; Cordeiro, Ines ; Salatino, Antonio [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Inst Biociencias, BR-05508090 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
[3] Univ Estadual Campinas, Div Farmacol & Toxicol, BR-13081970 Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 21, n. 6, p. 972-977, NOV-DEC 2011.
Web of Science Citations: 9
Abstract

Croton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as ``dragon's blood{''} and ``pau-sangue{''}. Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 mu g/mL, in particular on cell lines NCI-H460 (GI50 0.33 mu g/mL) and K5662 (GI50 0.91 mu g/mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes. (AU)

FAPESP's process: 08/09942-0 - Chemical diversity, genetic polymorphism and pharmacological activities of Croton (Euphorbiaceae)
Grantee:Lucimar Barbosa da Motta
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 08/10595-3 - Chemical diversity, genetic polymorphism and pharmacological activities of Croton (Euphorbiaceae)
Grantee:Antonio Salatino
Support Opportunities: Regular Research Grants