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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Epicolactone - Natural Product Isolated from the Sugarcane Endophytic Fungus Epicoccum nigrum

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da Silva Araujo, Francisca Diana [1] ; de Lima Favaro, Leia Cecilia [2] ; Araujo, Welington Luiz [3] ; de Oliveira, Fabio Lazzarotto [1] ; Aparicio, Ricardo [1] ; Marsaioli, Anita Jocelyne [1]
Total Authors: 6
[1] Univ Estadual Campinas, Inst Chem, BR-13084971 Campinas, SP - Brazil
[2] Embrapa Agroenergia, Brazilian Agr Res Corp, Brasilia, DF - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; v. 2012, n. 27, p. 5225-5230, SEP 2012.
Web of Science Citations: 32

The endophytic fungus Epicoccum nigrum was isolated from sugarcane and the bioguided fractionation of the ethyl acetate extract led to the isolation of epicolactone, mellein, and 4,5-dimethylresorcinol. Characterization of epicolactone by MS, NMR and X-ray crystallography revealed a new natural product with an unusual carbon skeleton. The production of this secondary metabolite decreased in mutants of Epicoccum nigrum transformed by Agrobacterium tumefaciens. Additionally, these mutants produced 4-hydroxymellein. (AU)

FAPESP's process: 10/08286-2 - Identification of genes from endophytic fungi Epicoccum purpurascens and Epicoccum sp. involved in the biosynthesis of antimicrobial compounds
Grantee:Welington Luiz de Araújo
Support Opportunities: Regular Research Grants