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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Short sleep duration and obesity: mechanisms and future perspectives

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Zimberg, Iona Zalcman [1, 2] ; Damaso, Ana [2, 3] ; Del Re, Mariana [1, 2] ; Carneiro, Aline Millani [2] ; Souza, Helton de Sa [2] ; de Lira, Fabio Santos [1, 2, 4] ; Tufik, Sergio [1] ; de Mello, Marco Tulio [1, 2]
Total Authors: 8
[1] Univ Fed Sao Paulo, Dept Psicobiol, BR-04020050 Sao Paulo - Brazil
[2] CEPE, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Biociencias, Santos - Brazil
[4] Univ Extremo Catarinense, Lab Fisiol & Bioquim Exercicio, Criciuma, SC - Brazil
Total Affiliations: 4
Document type: Review article
Source: Cell Biochemistry and Function; v. 30, n. 6, p. 524-529, AUG 2012.
Web of Science Citations: 32

A reduction of sleep time has become common over the last century, and growing evidence from both epidemiological and laboratory-based studies suggests sleep curtailment is a new risk factor for the development of obesity. On this basis, the present review examines the role of sleep curtailment in the metabolic and endocrine alterations, including decreased glucose tolerance and insulin sensitivity, increased evening concentrations of cortisol, increased levels of ghrelin, decreased levels of leptin and increased hunger and appetite. It will be discussed how sleep restriction may lead to increase in food intake and result in greater fatigue, which may favour decreased energy expenditure. Altogether, evidences point to a possible role of decreased sleep duration in the current epidemic of obesity and therefore present literature highlights the importance of getting enough good sleep for metabolic health. Many aspects still need to be clarified and intervention studies also need to be conducted. Copyright (c) 2012 John Wiley \& Sons, Ltd. (AU)

FAPESP's process: 08/09565-2 - The influence of sleep restriction on food intake and postprandial metabolism of obese subjetcs
Grantee:Ioná Zalcman Zimberg
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 98/14303-3 - Center for Sleep Studies
Grantee:Sergio Tufik
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 09/05657-2 - The influence of sleep restriction on food intake and postprandial metabolism of obese subjetcs
Grantee:Marco Túlio de Mello
Support Opportunities: Regular Research Grants
FAPESP's process: 06/00684-3 - Orexigenic, anorexigenic, pro and pre-inflamatory factors: effects of a multidisciplinary program for weight reduction in obese adolescents
Grantee:Ana Raimunda Dâmaso
Support Opportunities: Regular Research Grants