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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Relationship among Salivary Carbonic Anhydrase VI Activity and Flow Rate, Biofilm pH and Caries in Primary Dentition

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Frasseto, F. [1] ; Parisotto, T. M. [1] ; Peres, R. C. R. [1] ; Marques, M. R. [1] ; Line, S. R. P. [1] ; Nobre dos Santos, M. [1]
Total Authors: 6
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Piracicaba - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Caries Research; v. 46, n. 3, p. 194-200, 2012.
Web of Science Citations: 12

This study aimed to determine the activity of carbonic anhydrase isoenzyme VI (CAVI) in the saliva of preschool children with caries and to investigate the relationship between caries and salivary CAVI activity, salivary flow rate and biofilm pH before and after a 20% sucrose rinse. Thirty preschool children aged 45.3-80.3 months were divided into two groups: a caries-free group and a caries group. Clinical examinations were conducted by one examiner (kappa = 0.95) according to WHO criteria (dmfs) and early caries lesions. From each subject, CAVI activity, salivary flow rate and plaque pH were determined before and after a sucrose rinse. The results were submitted to Wilcoxon, Mann-Whitney and Spearman correlation tests (alpha = 0.05). The results showed that prerinse CAVI activity and its variation were higher in the saliva from caries children than from caries-free children. No difference was found between the two groups in postrinse salivary CAVI activity. After rinsing, biofilm pH differences were lower in both groups (p = 0.0012 and p = 0.0037 for the caries and caries-free groups, respectively). Also, after the sucrose rinse, salivary flow rate significantly increased in caries and caries-free groups (p = 0.0003, p = 0.0037). The variation of salivary CAVI activity was negatively correlated with caries (r = -0.501, p = 0.005). Child's age showed a positive correlation with caries (r = 0.456, p = 0.011). These results suggest that variation of salivary CAVI activity and child's age are associated with dental caries in preschool children. Copyright (C) 2012 S. Karger AG, Basel (AU)

FAPESP's process: 08/10064-8 - Study of the carbonic anhydrase VI activity and its association with biochemical parameters and pH of dental biofilm in preschool children with early childhood caries
Grantee:Marines Nobre dos Santos Uchôa
Support type: Regular Research Grants
FAPESP's process: 08/02412-6 - Study of the carbonic anhydrase VI activity and its association with biofilm biochemical parameters and early childhood caries in pre-school children
Grantee:Fernanda Frasseto
Support type: Scholarships in Brazil - Master