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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Class distinction between follicular adenomas and follicular carcinomas of the thyroid gland on the basis of their signature expression

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Stolf, Beatriz S. ; Santos, Mariana M. S. ; Simao, Daniel F. ; Diaz, Juan P. ; Cristo, Elier B. ; Hirata Júnior, Roberto ; Curado, Maria P. ; Neves, Eduardo J. ; Kowalski, Luiz P. ; Carvalho, Alex F.
Total Authors: 10
Document type: Journal article
Source: Cancer; v. 106, n. 9, p. 1891-1900, May 2006.
Field of knowledge: Health Sciences - Medicine

Nodules of the thyroid gland are observed frequently in patients who undergo ultrasound studies. The majority of these nodules are benign, corresponding to goiters or adenomas, and only a small fraction corresponds to carcinomas. Among thyroid tumors, the diagnosis of follicular adenocarcinomas by preoperative fine-needle aspiration biopsy is a major challenge, because it requires inspection of the entire capsule to differentiate it from adenoma. Consequently, large numbers of patients undergo unnecessary thyroidectomy. Using data from gene expression analysis, the authors applied Fisher linear discriminant analysis and searched for expression signatures of individual samples of adenomas and follicular carcinomas that could be used as molecular classifiers for the precise classification of malignant and nonmalignant lesions. Fourteen trios of genes were described that fulfilled the criteria for the correct classification of 100% of samples. The robustness of these trios was verified by using leave-1-out cross-validation and bootstrap analyses. The results demonstrated that, by combining trios, better classifiers could be generated that correctly classified >92% of samples. The strategy of classifiers based on individual signatures was a useful strategy for distinguishing between samples with very similar expression profiles. (AU)

FAPESP's process: 99/11962-9 - Critical Phenomena in envolving processes and equilibrium systems
Grantee:Pablo Augusto Ferrari
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 99/07390-0 - Cooperation for Analysis of Gene Expression - CAGE
Grantee:Hugo Aguirre Armelin
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 98/14335-2 - Antonio Prudente Cancer Research Center
Grantee:Fernando Augusto Soares
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC