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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV

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Machado, Daisy Maria [1, 2] ; Fink, Maria Cristina [2] ; Pannuti, Claudio Sergio [2] ; de Menezes Succi, Regina Celia [1] ; Machado, Alessandra Aparecida [2] ; do Carmo, Fabiana Bononi [1] ; Barbosa Gouvea, Aida de Fatima [1] ; Urbano, Paulo Roberto [2] ; Beltrao, Suenia Vasconcelos [1] ; Lopes dos Santos, Isabel Cristina [1] ; Machado, Clarisse Martins [2]
Total Authors: 11
[1] Univ Fed Sao Paulo, Disciplina Infectol Pediat, Dept Pediat, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Med Trop Sao Paulo, Virol Lab, BR-05403000 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Memórias do Instituto Oswaldo Cruz; v. 106, n. 8, p. 931-935, DEC 2011.
Web of Science Citations: 12

The aim of this study was to characterize the urinary excretion of the BK (BKV) and JC (JCV) human polyomaviruses in a cohort of human immunodeficiency virus (HIV)-infected children and adolescents. One hundred and fifty-six patients were enrolled: Group I included 116 HIV-infected children and adolescents [median age = 11.4 years (y); range 1-22 y]; Group II included 40 non-HIV-infected healthy controls (median age = 11.37 y; range 7-16 y). Single urine samples from both groups were screened for the presence of JCV and BKV DNA by polymerase chain reaction at enrolment. The overall rate of JCV and BKV urinary excretion was found to be 24.4% and 40.4%, respectively (n = 156). Group I had urinary excretion of JCV and BKV in 27.6% and 54.3% of subjects, respectively. In contrast, Group II showed positive results for JCV in 17.5% of subjects and for BKV in 12.5% of subjects (p Pearson JCV = 0.20; p Pearson BKV < 0.0001). In Group I, there was no association between JCV/BKV shedding and age, gender or CD4 values. Patients with an HIV viral load < 50 copies/mL had a lower excretion of BKV (p < 0.001) and a trend of lower JCV excretion (p = 0.07). One patient in Group I (1/116, 0.9%) showed clinical and radiological features consistent with progressive multifocal leukoencephalopathy, suggesting that children with HIV/polyomavirus coinfection should be kept under surveillance. (AU)

FAPESP's process: 07/06687-7 - Urinary excretion of poliomavirus in children and adolescents infected with Human Immunodeficiency Virus (HIV)
Grantee:Daisy Maria Machado
Support Opportunities: Regular Research Grants