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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Neuropathology and behavioral impairments after three types of global ischemia surgery in Meriones unguiculatus: Evidence in motor cortex, hippocampal CA1 region and the neostriatum

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Buiatti de Araujo, Fernanda Lopes [1] ; Bertolino, Guilherme [1] ; Goncalves, Renata Batagini [1] ; Marini, Luana de Castro [1] ; Coimbra, Norberto Cysne [2] ; de Araujo, Joao Eduardo [1]
Total Authors: 6
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Lab Neuropsychobiol & Motor Behav, Dept Biomech Med & Rehabil Locomotor Syst, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Lab Neuroanat & Neuropsychobiol, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: JOURNAL OF THE NEUROLOGICAL SCIENCES; v. 312, n. 1-2, p. 73-78, JAN 15 2012.
Web of Science Citations: 9

The effects of three types of global ischemia by occlusion of carotid artery on motor and exploratory behaviors of Gerbils were evaluated by the Activity Cage and Rota rod tests. Animals were divided based on two surgical criteria: unilateral (UNI) or bilateral (BIL) carotid occlusion, with (REP) or without (OCL) reperfusion; and their behavior was evaluated on the fourth (4) or sixth (6) day. There was reduction of cell number in striatum, motor cortex M1 area, and hippocampal CA1 area in all groups in comparison to control animals. For M1 area and striatum, the largest reduction was observed in UNI6, UNI4, and BIL4 groups. Neuronal loss was also observed in CA1 area of BIL4 rodents. There was a decrease in crossings and rearings in all groups in activity cage test, compared to control. Reperfusion, unilateral and bilateral occlusion groups showed decrease in crossings. Only the BIL4 showed a decrease of rearing. In the Rota rod test, except the UNIOCL6, the groups showed a decrease in the balance in comparison to control. Both groups with REP4 showed a major decrease in balance. These findings suggest that both unilateral and bilateral carotid occlusions with reperfusion produce impairments of motor and exploratory behavior. (C) 2011 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 05/02607-3 - Behavioural effects and neuronal apoptosis alteration induced for the continuous and not continuous treadmill training pós-ischemia cerebral unilateral in Gerbils
Grantee:João Eduardo de Araujo
Support Opportunities: Regular Research Grants