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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Erysothrine, an alkaloid extracted from flowers of Erythrina mulungu Mart. ex Benth: Evaluating its anticonvulsant and anxiolytic potential

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Rosa, Daiane Santos [1] ; Faggion, Silmara Aparecida [1] ; Gavin, Amanda Salomao [1] ; de Souza, Maicon Anderson [1] ; Fachim, Helene Aparecida [2] ; dos Santos, Wagner Ferreira [2] ; Pereira, Ana Maria Soares [1] ; Cunha, Alexandra Olimpio Siqueira [3] ; Beleboni, Rene Oliveira [1]
Total Authors: 9
[1] Univ Ribeirao Preto, Dept Biotechnol, Ribeirao Preto - Brazil
[2] Univ Sao Paulo, FFCLRP, Dept Biol, Sao Paulo - Brazil
[3] Univ Sao Paulo, FMRP, Dept Physiol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Epilepsy & Behavior; v. 23, n. 3, p. 205-212, MAR 2012.
Web of Science Citations: 18

In this study, we isolated the alkaloid erysothrine from the hydroalcoholic extract of flowers from E. mulungu and screened for its anticonvulsant and anxiolytic actions based on neuroethological and neurochemical experiments. Our results showed that the administration of erysothrine inhibited seizures evoked by bicuculline, PTZ, NMDA and most remarkably, kainic acid. Also, erysothrine induced an increase in the number of entries but not in the time spent in the open arms of the EPM. However, we did not notice any alterations in the light-dark choice or in the open-field tests. In preliminary neurochemistry tests, we also showed that erysothrine (0.001-10 mu g/mL) did not alter the GABA or glutamate synaptossomal uptake and binding. Altogether, our results describe an alkaloid with anticonvulsant activity and mild anxiolytic activity that might be considered well tolerated as it does not alter the general behavior of the animals in the used doses. (C) 2012 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 09/11357-1 - Neuroethological and neurochemical characterization of alkaloids isolated from Erythrina mulungu (Leguminosae-Papilionaceae) flower hydroalcoholic extract
Grantee:Renê de Oliveira Beleboni
Support Opportunities: Regular Research Grants