Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Haptoglobin genotypes in Chagas' disease

Full text
Jorge, Susan E. D. C. [1] ; Abreu, Cristina Feix [1] ; Guariento, Maria Elena [2] ; Sonati, Maria de Fatima [1]
Total Authors: 4
[1] State Univ Campinas UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP - Brazil
[2] State Univ Campinas UNICAMP, Sch Med Sci, Dept Clin Med, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CLINICAL BIOCHEMISTRY; v. 43, n. 3, p. 314-316, FEB 2010.
Web of Science Citations: 7

Objectives: To investigate the existence of an association between haptoglobin (Hp) genotypes and the severity of heart complications in Chagas' disease. Design and methods: Hp genotyping was performed by PCR in 107 Brazilian patients sub-classified in asymptomatic, with mild heart disease and with severe heart disease. Results: Multiple logistic regression (R(2) = 24%) indicated that patients with the Hp1-1 genotype have lower probability of developing the severe heart complications. Conclusion: The Hp polymorphism may influence the clinical evolution of Chagas' disease. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 08/01690-2 - Haptoglobin Genotypes in Sickle Cell Diseases
Grantee:Maria de Fatima Sonati
Support Opportunities: Regular Research Grants