| Full text | |
| Author(s): |
Jorge, Susan E. D. C.
[1]
;
Abreu, Cristina Feix
[1]
;
Guariento, Maria Elena
[2]
;
Sonati, Maria de Fatima
[1]
Total Authors: 4
|
| Affiliation: | [1] State Univ Campinas UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP - Brazil
[2] State Univ Campinas UNICAMP, Sch Med Sci, Dept Clin Med, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | CLINICAL BIOCHEMISTRY; v. 43, n. 3, p. 314-316, FEB 2010. |
| Web of Science Citations: | 7 |
| Abstract | |
Objectives: To investigate the existence of an association between haptoglobin (Hp) genotypes and the severity of heart complications in Chagas' disease. Design and methods: Hp genotyping was performed by PCR in 107 Brazilian patients sub-classified in asymptomatic, with mild heart disease and with severe heart disease. Results: Multiple logistic regression (R(2) = 24%) indicated that patients with the Hp1-1 genotype have lower probability of developing the severe heart complications. Conclusion: The Hp polymorphism may influence the clinical evolution of Chagas' disease. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 08/01690-2 - Haptoglobin Genotypes in Sickle Cell Diseases |
| Grantee: | Maria de Fatima Sonati |
| Support Opportunities: | Regular Research Grants |