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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Syzygium jambolanum treatment improves survival in lethal sepsis induced in mice

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Maciel, Marcia C. G. [1] ; Farias, Jardel C. [1] ; Maluf, Michele J. [1] ; Gomes, Eliane A. [2] ; Pereira, Paulo V. S. [1] ; Aragao-Filho, Walmir C. [1] ; Frazao, Josias B. [1] ; Costa, Graciomar C. [1] ; Sousa, Sanara M. [1] ; Silva, Lucilene A. [1] ; Amaral, Flavia M. M. [1] ; Russo, Momtchilo [2] ; Guerra, Rosane N. M. [1] ; Nascimento, Flavia R. F. [1]
Total Authors: 14
[1] Univ Fed Maranhao, Immunophysiol Lab, Sao Paulo, MA - Brazil
[2] Univ Sao Paulo, Immunobiol Lab, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Web of Science Citations: 13

Background: The leaves and the fruits from Syzygium jambolanum DC.(Myrtaceae), a plant known in Brazil as sweet olive or `jambolao', have been used by native people to treat infectious diseases, diabetes, and stomachache. Since the bactericidal activity of S. jambolanum has been confirmed in vitro, the aim of this work was to evaluate the effect of the prophylactic treatment with S. jambolanum on the in vivo polymicrobial infection induced by cecal ligation and puncture (CLP) in mice. Methods: C57BI/6 mice were treated by the subcutaneous route with a hydroalcoholic extract from fresh leaves of S. jambolanum (HCE). After 6 h, a bacterial infection was induced in the peritoneum using the lethal CLP model. The mice were killed 12 h after the CLP induction to evaluate the cellular influx and local and systemic inflammatory mediators' production. Some animals were maintained alive to evaluate the survival rate. Results: The prophylactic HCE treatment increased the mice survival, the neutrophil migration to infectious site, the spreading ability and the hydrogen peroxide release, but decreased the serum TNF and nitrite. Despite the increased migration and activation of peritoneal cells the HCE treatment did not decrease the number of CFU. The HCE treatment induced a significant decrease on the bone marrow cells number but did not alter the cell number of the spleen and lymph node. Conclusion: We conclude that the treatment with S. jambolanum has a potent prophylactic antiseptic effect that is not associated to a direct microbicidal effect but it is associated to a recruitment of activated neutrophils to the infectious site and to a diminished systemic inflammatory response. (AU)

FAPESP's process: 04/14297-6 - Activation/deactivation of macrophages and CD4+ T lymphocytes in experimental asthma
Grantee:Momtchilo Russo
Support Opportunities: Research Projects - Thematic Grants