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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Comparative evaluation of the erbB2 and hormone receptor status of neighboring invasive and in situ components of ductal carcinomas of the breast

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Rodrigues Peres, Raquel Mary [1] ; Serra, Katia Piton [2] ; Derchain, Sophie F. M. [2] ; Yoon, Jung Hyun ; Pinto, Glauce Aparecida [1] ; Alvarenga, Marcelo [2] ; Soares, Fernando Augusto [3] ; Heinrich, Juliana K. [1] ; da Cunha, Isabela Werneck [3] ; Vassallo, Jose ; Sarian, Luis Otavio [2]
Total Authors: 11
[1] Univ Estadual Campinas, CAISM, Womens Hosp, BR-13083881 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Med Sci, Dept Obstet & Gynecol, BR-13083881 Campinas, SP - Brazil
[3] Hosp Canc AC Camargo, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: International Journal of Biological Markers; v. 24, n. 4, p. 238-244, OCT-DEC 2009.
Web of Science Citations: 1

Background: It remains unknown whether erbB2 expression and hormone receptor status predict the invasive potential of ductal carcinoma in situ (DCIS) of the breast. Objectives: To examine erbB2 and estrogen/progesterone receptor (ER/PR) status in the precise areas where DCIS turns into invasive ductal carcinoma (IDC). Subjects and methods: Eighty-seven cases of breast malignancies harboring contiguous regions of DCIS and IDC were selected. Separate histological samples from the DCIS and the neighboring IDC were obtained using tissue microarrays. The erbB2 and ER/PR statuses were assessed using immunohistochemistry (erbB2 and ER/PR) and fluorescence in situ hybridization (FISH only erbB2). Results: The expression of erbB2 did not differ in the DCIS and IDC components of the breast tumors (p=0.35). There was good agreement in sample-by-sample comparisons of erbB2 (intraclass correlation coefficient {[}ICC]=0.78), PR (ICC=0.61) and ER (ICC=0.70) expression in the DCIS and IDC components. Conclusion: Our findings suggest that the expressions of erbB2 and ER/PR do not differ in the contiguous regions from DCIS to IDC. (Int J Biol Markers 2009; 24: 238-44) (AU)

FAPESP's process: 08/02469-8 - Genomic instability in breast malignant tumors as related to the concentration of intracelular aluminium and to estrogen receptor status
Grantee:Luís Otávio Zanatta Sarian
Support type: Regular Research Grants
FAPESP's process: 08/08536-9 - Expression of COX-2 in invasive and in situ breast carcinoma and its relation to HER2 expression, p53 mutation and estrogen and progesterone receptors
Grantee:Sophie Françoise Mauricette Derchain
Support type: Regular Research Grants