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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impact of photodynamic therapy on inflammatory cells during human chronic periodontitis

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Seguier, Sylvie [1, 2, 3] ; Souza, Sergio L. S. [4] ; Sverzut, Anna C. V. [4] ; Simioni, Andreza R. [1] ; Primo, Fernando L. [1] ; Bodineau, Agnes [2, 3] ; Correa, Vani M. A. [5] ; Coulomb, Bernard [2] ; Tedesco, Antonio C. [1]
Total Authors: 9
[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto FF, Dept Quim, BR-14040901 Ribeirao Preto, SP - Brazil
[2] Univ Paris 05, Hop Europeen Georges Pompidou, F-75737 Paris 15 - France
[3] Hop Louis Mourier, Serv Odontol, F-92700 Colombes - France
[4] Univ Sao Paulo, Fac Odontol FORP, Dept Cirurgia Traumatol Buco Maxilo & Facial Peri, BR-14040904 Ribeirao Preto, SP - Brazil
[5] Univ Sao Paulo, Fac Med FMRP, Dept Biol Celular & Mol & Bioagentes Patogen, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Web of Science Citations: 29

The aim of this study was to evaluate the effects of the photodynamic therapy (PDT) on the inflammatory infiltrate and on the collagen network organization in human advanced chronic periodontitis Two different drug delivery systems (DDS) were tested (liposomes and nanoemulsions) to determine if the effects of PDT could differ according to the DDS used Sixteen patients presenting two teeth with chronic advanced periodontitis and Important tooth mobility with clinical indication of extraction were included in the group liposomes (group L n = 8) or in the group nanoemulsions (group N n = 8) in order to compare the effects of each DDS Seven days before extractions one tooth of each patient was treated with PDT using phthalocyanine derivatives as photosensitizers and the contralateral tooth was taken as control In group L the density of gingival collagen fibers (66 +/- 19%) was significantly Increased (p < 0 02) when compared to controls (35 +/- 21%) Concerning the antigen-presenting cells PDT had differential effects depending on the drug delivery system the number of macrophages was significantly decreased (p < 0 05) in group L while the number of Langerhans cells was significantly decreased in group N (p < 0 02) These findings demonstrate that PDT presents an impact on gingival Inflammatory phenomenon during chronic periodontitis and leads to a specific decrease of antigen-presenting cells populations according to the drug delivery system used (C) 2010 Elsevier B V All rights reserved (AU)

FAPESP's process: 08/53719-4 - Use of nanocarriers containing photosensitive dyes and other derived and growing factors applied to the photodynamic process in the health areas
Grantee:Antonio Claudio Tedesco
Support type: Research Projects - Thematic Grants