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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

No relationship found between point heteroplasmy in mitochondrial DNA control region and age range, sex and haplogroup in human hairs

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Author(s):
de Camargo, Maria Angelica [1] ; Paneto, Greiciane G. [1] ; de Mello, Aline C. O. [1] ; Martins, Joyce A. [1] ; Barcellos, William [2] ; Cicarelli, Regina M. B. [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Paulista, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP - Brazil
[2] Univ Sao Paulo, USP, Sch Engn Sao Carlos, BR-13566590 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: MOLECULAR BIOLOGY REPORTS; v. 38, n. 2, p. 1219-1223, FEB 2011.
Web of Science Citations: 12
Abstract

The analysis of heteroplasmy (presence of more than one type of mitochondrial DNA in an individual) is used as a tool in human identification studies, anthropology, and most currently in studies that relate heteroplasmy with longevity. The frequency of heteroplasmy and its correlation with age has been analyzed using different tissues such as blood, muscle, heart, bone and brain and in different regions of mitochondrial DNA, but this analysis had never been performed using hair samples. In this study, samples of hair were sequenced in order to ascertain whether the presence or not of heteroplasmy varied according to age, sex and origin of haplogroup individuals. The samples were grouped by age (3 groups), gender (male and female) and haplogroup of origin (European, African and Native American), and analyzed using the chi-square statistical test (chi(2)). Based in statistical results obtained, we conclude that there is no relationship between heteroplasmy and sex, age and haplogroup origin using hair samples. (AU)

FAPESP's process: 07/05647-1 - MITOCHONDRIAL DNA HETEROPLASMY ANALYSIS IN HAIR AND BLOOD SAMPLES
Grantee:Maria Angélica de Camargo
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 00/00251-3 - Investigation of optical, paramagnetic and luminescence properties on natural Brazilian silicate crystals due to point defects
Grantee:Shigueo Watanabe
Support type: Research Projects - Thematic Grants