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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-alpha-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae)

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Faggion, Silmara Aparecida [1] ; Siqueira Cunha, Alexandra Olimpio [2] ; Fachim, Helene Aparecida [2] ; Gavin, Amanda Salomao [1] ; dos Santos, Wagner Ferreira [2] ; Soares Pereira, Ana Maria [1] ; Beleboni, Rene Oliveira [1]
Total Authors: 7
[1] Univ Ribeirao Preto UNAERP, Dept Biotechnol, Sao Paulo - Brazil
[2] Univ Sao Paulo, FFCLRP, Dept Biol, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Epilepsy & Behavior; v. 20, n. 3, p. 441-446, MAR 2011.
Web of Science Citations: 22

Neural mechanisms underlying the onset and maintenance of epileptic seizures involve alterations in inhibitory and/or excitatory neurotransmitter pathways. Thus, the prospecting of novel molecules from natural products that target both inhibition and excitation systems has deserved interest in the rational design of new anticonvulsants. We isolated the alkaloids (+)-erythravine and ( +)-11-alpha-hydroxyerythravine from the flowers of Erythrina mulungu and evaluated the action of these compounds against chemically induced seizures in rats. Our results showed that the administration of different doses of (+)-erythravine inhibited seizures evoked by bicuculline, pentylenetetrazole, and kainic acid at maximum of 80, 100, and 100%, respectively, whereas different doses of (+)-11-alpha-hydroxy-erythravine inhibited seizures at a maximum of 100% when induced by bicuculline, NMDA, and kainic acid, and, to a lesser extent, PTZ (60%). The analysis of mean latency to seizure onset of nonprotected animals, for specific doses of alkaloids, showed that (+)-erythravine increased latencies to seizures induced by bicuculline. Although (+)-erythravine exhibited very weak anticonvulsant action against seizures induced by NMDA, this alkaloid increased the latency in this assay. The increase in latency to onset of seizures promoted by (+)-11-alpha-hydroxy-erythravine reached a maximum of threefold in the bicuculline test. All animals were protected against death when treated with different doses of (+)-11-alpha-hydroxy-erythravine in the tests using the four chemical convulsants. Identical results were obtained when using (+)-erythravine in the tests of bicuculline, NMDA, and VIZ, and, to a lesser extent, kainic acid. Therefore, these data validate the anticonvulsant properties of the tested alkaloids, which is of relevance in consideration of the ethnopharmacological/biotechnological potential of E. mulungu. (C) 2010 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 09/11357-1 - Neuroethological and neurochemical characterization of alkaloids isolated from Erythrina mulungu (Leguminosae-Papilionaceae) flower hydroalcoholic extract
Grantee:Renê de Oliveira Beleboni
Support Opportunities: Regular Research Grants