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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Environmentally induced antinociception and hyperalgesia in rats and mice

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Author(s):
Cornelio, Alianda Maira [1, 2, 3] ; Mendes-Gomes, Joyce [1, 4] ; Fugimoto, Juliana Sayuri [1] ; Morgan, Michael M. [3] ; Nunes-de-Souza, Ricardo Luiz [1, 2]
Total Authors: 5
Affiliation:
[1] UNESP, Fac Ciencias Farmaceut, Farmacol Lab, BR-14801902 Araraquara, SP - Brazil
[2] UNESP, UFSCar, Programa Interinst Posgrad Ciencias Fisiol, BR-14801902 Araraquara, SP - Brazil
[3] Washington State Univ Vancouver, Dept Psychol, Vancouver, WA 98686 - USA
[4] USP, FFCLRP, Programa Posgrad Psicobiol, BR-14040901 Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Brain Research; v. 1415, p. 56-62, SEP 30 2011.
Web of Science Citations: 10
Abstract

Stress can enhance and inhibit nociception depending on the situation. Thus, simply shifting the context from the elevated plus maze (EPM) which has been shown to produce stress-induced antinociception to a different environment could produce drastic and rapid changes in nociception. The present experiment tested this hypothesis by assessing nociception in rats and mice during and immediately after removal from the maze. Experiment 1 found hyperalgesia in female and male rats tested on the hot plate immediately after exposure to the elevated plus maze. This hyperalgesia occurred with or without the added stress of a hind paw formalin injection and regardless of whether rats were exposed to an EPM with open (oEPM) or enclosed (eEPM) arms despite a clear antinociceptive effect while on the oEPM. Experiment 2 showed a similar shift from antinociception to nociception on the formalin test in mice immediately after removing them from the EPM. These data demonstrate that a mild stressor such as the EPM can produce both antinociception and hyperalgesia depending on the context. This shift from antinociception to hyperalgesia occurs rapidly and is evident in mice, male and female rats, and with the hot plate and formalin tests. (C) 2011 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 05/01988-3 - Role of dorsal and ventrolateral portions of the periaqueductal gray in the modulation of defensive behaviors and antinociception induced by aversive situations in mice
Grantee:Joyce Mendes Gomes Tessari
Support type: Scholarships in Brazil - Doctorate (Direct)