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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Increased Reactive Oxygen Species and Tumor Necrosis Factor-Alpha Production by Monocytes are Associated with Elevated Levels of Uric Acid in Pre-Eclamptic Women

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Peracoli, Maria T. S. [1] ; Bannwart, Camila F. [2] ; Cristofalo, Renata [1] ; Medeiros Borges, Vera T. [2] ; Araujo Costa, Roberto A. [2] ; Witkin, Steven S. [3] ; Peracoli, Jose C. [2]
Total Authors: 7
[1] UNESP Sao Paulo State Univ, Dept Microbiol & Immunol, Inst Biociences, Sao Paulo - Brazil
[2] UNESP Sao Paulo State Univ, Dept Obstet & Ginecol, Botucatu Med Sch, Sao Paulo - Brazil
[3] Cornell Univ, Div Immunol & Infect Dis, Weill Med Coll, Dept Obstet & Gynecol, New York, NY 10021 - USA
Total Affiliations: 3
Document type: Journal article
Source: American Journal of Reproductive Immunology; v. 66, n. 6, p. 460-467, DEC 2011.
Web of Science Citations: 28

Problem To evaluate associations between hyperuricemia and increases in production of reactive oxygen species (ROS) and tumor necrosis factor alpha (TNF-alpha) in pre-eclamptic pregnancies. Method of study This study investigated serum uric acid levels, monocyte production of TNF-alpha, superoxide anion (O(2)(-)) and hydrogen peroxide (H(2)O(2)), as well as superoxide dismutase (SOD) and catalase (CAT) activities in erythrocytes from 30 women with pre-eclampsia (PE) compared with 30 normotensive (NT) pregnant women in the last trimester of pregnancy. Results Serum uric acid levels (6.1 versus 2.8 mg/dL) as well as endogenous O(2)(-) (2.2 versus 1.6 nm), H(2)O(2) (1.8 versus 1.4 nm) and TNF-alpha (91.6 versus 40.4 pg/mL) released from monocytes were significantly higher in the pre-eclamptic group than in the NT group (P < 0.05). SOD activity in erythrocytes was also significantly elevated in the PE group (5969.2 versus 4834.7 U/g Hb). No significant difference between groups was observed in relation to CAT activity. Conclusions Elevated serum uric acid levels are correlated with higher O(2)(-) and TNF-alpha production by monocytes in women with PE. This may contribute to the enhanced oxidative and inflammatory state characteristic of this disorder. (AU)