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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Macrophages: key players in erythrocyte turnover

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Author(s):
Marina Dorigatti Borges [1] ; Renata Sesti-Costa [2]
Total Authors: 2
Affiliation:
[1] University of Campinas, UNICAMP. Hematology and Hemotherapy Center - Brasil
[2] University of Campinas, UNICAMP. Hematology and Hemotherapy Center - Brasil
Total Affiliations: 2
Document type: Journal article
Source: Hematology, Transfusion and Cell Therapy; v. 44, n. 4, p. 574-581, 2022-12-12.
Abstract

ABSTRACT The development of red blood cells (RBCs), or erythropoiesis, occurs in specialized niches in the bone marrow, called erythroblastic islands, composed of a central macrophage surrounded by erythroblasts at different stages of differentiation. Upon anemia or hypoxemia, erythropoiesis extends to extramedullary sites, mainly spleen and liver, a process known as stress erythropoiesis, leading to the expansion of erythroid progenitors, iron recruitment and increased production of reticulocytes and mature RBCs. Macrophages are key cells in both homeostatic and stress erythropoiesis, providing conditions for erythroid cells to survive, proliferate and differentiate. During RBCs aging and injury, macrophages play a fundamental role again, performing the clearance of these cells and recycling iron for new erythroblasts in development. Thus, macrophages are crucial components of the RBCs turnover and in this review, we aimed to cover the main known mechanisms involved in the process of birth and death of RBCs, highlighting the importance of macrophage functions in the whole RBC lifecycle. (AU)

FAPESP's process: 21/05191-5 - Dendritic cells in sickle cell anemia: molecular mechanisms involved in the regulation of inflammation and adaptive immune response
Grantee:Renata Sesti Costa
Support Opportunities: Scholarships in Brazil - Young Researchers
FAPESP's process: 19/09704-7 - Dendritic cells in Sickle Cell Anemia: molecular mechanisms involved in regulating inflammation and adaptive immune response
Grantee:Renata Sesti Costa
Support Opportunities: Research Grants - Young Investigators Grants